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Alcohol consumption and 5-year onset of chronic kidney disease: The AusDiab study

White, Sarah L., Polkinghorne, Kevan R., Cass, Alan, Shaw, Jonathan E., Atkins, Robert C. and Chadban, Steven J. (2009). Alcohol consumption and 5-year onset of chronic kidney disease: The AusDiab study. Nephrology Dialysis Transplantation,24(8):2464-2472.

Document type: Journal Article

IRMA ID 84473293xPUB21
Title Alcohol consumption and 5-year onset of chronic kidney disease: The AusDiab study
Author White, Sarah L.
Polkinghorne, Kevan R.
Cass, Alan
Shaw, Jonathan E.
Atkins, Robert C.
Chadban, Steven J.
Journal Name Nephrology Dialysis Transplantation
Publication Date 2009
Volume Number 24
Issue Number 8
ISSN 0931-0509   (check CDU catalogue open catalogue search in new window)
Scopus ID 2-s2.0-67651097726
Start Page 2464
End Page 2472
Total Pages 8
Place of Publication United Kingdom
Publisher Oxford University Press
HERDC Category C1 - Journal Article (DIISR)
Abstract Background. Excessive alcohol consumption is a risk factor for hypertension and stroke; however, evidence for an association with chronic kidney disease is conflicting.

Methods. A total of 6259 adults ≥25 years of age, without a history of alcohol dependence, participating in baseline (1999–2000) and follow-up (2004–2005) phases of an Australian population-representative study (AusDiab) were the subject of this analysis. Alcohol consumption status and volume/frequency were collected by standardized interviewer administered questionnaires and self-administered food frequency questionnaires. The outcomes were as follows: (i) 5-year decline in estimated glomerular filtration rate (eGFR) ≥10%, with baseline eGFR ≥ 60 and final eGFR <60 mL/min/1.73 m2, and (ii) 5-year doubling of albumin to creatinine ratio (ACR) with final ACR ≥ 2.5 (males)/≥ 3.5 (females) mg/mmol, in the absence of albuminuria at baseline.

Results. Self-identification as a moderate or heavy, versus light, drinker was associated with elevated risk of albuminuria in males and females <65 years of age (OR, 95% CI: males 1.87, 0.99–3.52; females 2.38, 1.37–4.14). Odds of de novo eGFR <60 mL/min/1.73 m2 were 0.34 (95% CI 0.22–0.59) and 0.68 (95% CI 0.36–1.27) in males and females, respectively, who were moderate–heavy drinkers. Alcohol intake of ≥30 g/day was associated with an increased risk of albuminuria after adjustment for age, sex and baseline kidney function (OR = 1.59, 95% CI 1.07–2.36), but a reduced risk of eGFR <60 mL/min/1.73 m2 (OR = 0.59, 95% CI 0.37–0.95), compared with consumption of <10 g/day.

Conclusions. Moderate–heavy alcohol consumption may be an important modifiable risk factor for albuminuria in the general population. The natural history of alcohol-induced kidney damage and how this relates to markers of kidney function in the general population warrant further research.
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