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Design and challenges of the Randomized Evaluation of Normal versus Augmented Level Replacement Therapy (RENAL) Trial: High-dose versus standard-dose hemofiltration in acute renal failure

Bellomo, Rinaldo, Cass, Alan, Lole, Louise, Finfer, Simon, Goldsmith, Donna, Myburgh, John, Norton, Robyn, Scheinkestel, Carlos and The RENAL Study Investigators (2008). Design and challenges of the Randomized Evaluation of Normal versus Augmented Level Replacement Therapy (RENAL) Trial: High-dose versus standard-dose hemofiltration in acute renal failure. Blood Purification,26(5):407-416.

Document type: Journal Article

IRMA ID 84473293xPUB41
Title Design and challenges of the Randomized Evaluation of Normal versus Augmented Level Replacement Therapy (RENAL) Trial: High-dose versus standard-dose hemofiltration in acute renal failure
Author Bellomo, Rinaldo
Cass, Alan
Lole, Louise
Finfer, Simon
Goldsmith, Donna
Myburgh, John
Norton, Robyn
Scheinkestel, Carlos
The RENAL Study Investigators
Journal Name Blood Purification
Publication Date 2008
Volume Number 26
Issue Number 5
ISSN 0253-5068   (check CDU catalogue  open catalogue search in new window)
Scopus ID 2-s2.0-53949121395
Start Page 407
End Page 416
Total Pages 9
Place of Publication Switzerland
Publisher S. Karger AG
HERDC Category C1 - Journal Article (DIISR)
Abstract Background/Aims: The optimal dose of renal replacement therapy (RRT) in acute renal failure (ARF) is uncertain.

Methods: The Randomized Evaluation of Normal versus Augmented Level Replacement Therapy Trial tests the hypothesis that higher dose continuous veno-venous hemodiafiltration (CVVHDF) at an effluent rate of 40 ml/kg/h will increase survival compared to CVVHDF at 25 ml/kg/h of effluent dose.

Results: This trial is currently randomizing critically ill patients in 35 intensive care units in Australia and New Zealand with a planned sample size of 1,500 patients. This trial will be the largest trial ever conducted on acute blood purification in critically ill patients.

Conclusion: A trial of this magnitude and with demanding technical requirements poses design difficulties and challenges in the logistics, conduct, data collection, data analysis and monitoring. Our report will assist in the development of future trials of blood purification in intensive care.
DOI http://dx.doi.org/10.1159/000148400   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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