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Development of the RTS,S/AS malaria candidate vaccine

Vekemans, Johan, Leach, Amanda J. and Cohen, Joe (2009). Development of the RTS,S/AS malaria candidate vaccine. Vaccine,27(Suppl. 6):G67-G71.

Document type: Journal Article

IRMA ID 75039815xPUB410
Title Development of the RTS,S/AS malaria candidate vaccine
Author Vekemans, Johan
Leach, Amanda J.
Cohen, Joe
Journal Name Vaccine
Publication Date 2009
Volume Number 27
Issue Number Suppl. 6
ISSN 0264-410X   (check CDU catalogue open catalogue search in new window)
Scopus ID 2-s2.0-72049086178
Start Page G67
End Page G71
Place of Publication United Kingdom
Publisher Elsevier Ltd
HERDC Category C1 - Journal Article (DIISR)
Abstract A vaccine against malaria which complements existing control tools is an urgent medical need. RTS,S/AS, a pre-erythrocytic candidate vaccine, which targets the circumsporozoite protein, is the most advanced in clinical development. The safety, immunogenicity and efficacy of this candidate vaccine have been investigated in a series of trials in children and infants in endemic African countries. The vaccine shows promise for providing important public health benefits and a multicenter Phase III trial has started in Africa, aiming to further characterize the efficacy of the candidate vaccine and generate the regulatory data required for the licensing approval of the vaccine.
Keywords Malaria vaccine
RTS,S/AS
Development
DOI http://dx.doi.org/10.1016/j.vaccine.2009.10.013   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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Created: Tue, 24 Feb 2015, 12:34:30 CST