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Dominance of multidrug resistant CC271 clones in macrolide-resistant streptococcus pneumoniae in Arizona

Bowers, Jolene R., Driebe, Elizabeth M., Nibecker, Jennifer L., Wojack, Bette R., Sarovich, Derek S., Wong, Ada H., Brzoska, Pius M., Hubert, Nathaniel, Knadler, Andrew, Watson, Lindsey M., Wagner, David M., Furtado, Manohar R., Saubolle, Michael, Engelthaler, David M. and Keim, Paul S. (2012). Dominance of multidrug resistant CC271 clones in macrolide-resistant streptococcus pneumoniae in Arizona. BMC Microbiology,12:1-10.

Document type: Journal Article
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IRMA ID 75039815xPUB469
Title Dominance of multidrug resistant CC271 clones in macrolide-resistant streptococcus pneumoniae in Arizona
Author Bowers, Jolene R.
Driebe, Elizabeth M.
Nibecker, Jennifer L.
Wojack, Bette R.
Sarovich, Derek S.
Wong, Ada H.
Brzoska, Pius M.
Hubert, Nathaniel
Knadler, Andrew
Watson, Lindsey M.
Wagner, David M.
Furtado, Manohar R.
Saubolle, Michael
Engelthaler, David M.
Keim, Paul S.
Journal Name BMC Microbiology
Publication Date 2012
Volume Number 12
eISSN 1471-2180
Scopus ID 2-s2.0-84855882958
Start Page 1
End Page 10
Total Pages 10
Place of Publication United Kingdom
Publisher BioMed Central
HERDC Category C1 - Journal Article (DIISR)
Abstract Background
Rates of resistance to macrolide antibiotics in Streptococcus pneumoniae are rising around the world due to the spread of mobile genetic elements harboring mef(E) and erm(B) genes and post-vaccine clonal expansion of strains that carry them.

Characterization of 592 clinical isolates collected in Arizona over a 10 year period shows 23.6% are macrolide resistant. The largest portion of the macrolide-resistant population, 52%, is dual mef(E)/erm(B)-positive. All dual-positive isolates are multidrug-resistant clonal lineages of Taiwan19F-14, mostly multilocus sequence type 320, carrying the recently described transposon Tn2010. The remainder of the macrolide resistant S. pneumoniae collection includes 31% mef(E)-positive, and 9% erm(B)-positive strains.

The dual-positive, multidrug-resistant S. pneumoniae clones have likely expanded by switching to non-vaccine serotypes after the heptavalent pneumococcal conjugate vaccine release, and their success limits therapy options. This upsurge could have a considerable clinical impact in Arizona.
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Additional Notes This is an Open Access article distributed under the terms of the Creative Commons Attribution License 2.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Description for Link Link to CC Attribution 2.0 License

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