Charles Darwin University

CDU eSpace
Institutional Repository

 
CDU Staff and Student only
 

Dominance of multidrug resistant CC271 clones in macrolide-resistant streptococcus pneumoniae in Arizona

Bowers, Jolene R., Driebe, Elizabeth M., Nibecker, Jennifer L., Wojack, Bette R., Sarovich, Derek S., Wong, Ada H., Brzoska, Pius M., Hubert, Nathaniel, Knadler, Andrew, Watson, Lindsey M., Wagner, David M., Furtado, Manohar R., Saubolle, Michael, Engelthaler, David M. and Keim, Paul S. (2012). Dominance of multidrug resistant CC271 clones in macrolide-resistant streptococcus pneumoniae in Arizona. BMC Microbiology,12:1-10.

Document type: Journal Article
Attached Files (Some files may be inaccessible until you login with your CDU eSpace credentials)
Name Description MIMEType Size Downloads
Download this reading Sarovich_44321.pdf Published version application/pdf 349.37KB 29
Reading the attached file works best in Firefox, Chrome and IE 9 or later.

IRMA ID 75039815xPUB469
Title Dominance of multidrug resistant CC271 clones in macrolide-resistant streptococcus pneumoniae in Arizona
Author Bowers, Jolene R.
Driebe, Elizabeth M.
Nibecker, Jennifer L.
Wojack, Bette R.
Sarovich, Derek S.
Wong, Ada H.
Brzoska, Pius M.
Hubert, Nathaniel
Knadler, Andrew
Watson, Lindsey M.
Wagner, David M.
Furtado, Manohar R.
Saubolle, Michael
Engelthaler, David M.
Keim, Paul S.
Journal Name BMC Microbiology
Publication Date 2012
Volume Number 12
eISSN 1471-2180
Scopus ID 2-s2.0-84855882958
Start Page 1
End Page 10
Total Pages 10
Place of Publication United Kingdom
Publisher BioMed Central
HERDC Category C1 - Journal Article (DIISR)
Abstract Background
Rates of resistance to macrolide antibiotics in Streptococcus pneumoniae are rising around the world due to the spread of mobile genetic elements harboring mef(E) and erm(B) genes and post-vaccine clonal expansion of strains that carry them.

Results
Characterization of 592 clinical isolates collected in Arizona over a 10 year period shows 23.6% are macrolide resistant. The largest portion of the macrolide-resistant population, 52%, is dual mef(E)/erm(B)-positive. All dual-positive isolates are multidrug-resistant clonal lineages of Taiwan19F-14, mostly multilocus sequence type 320, carrying the recently described transposon Tn2010. The remainder of the macrolide resistant S. pneumoniae collection includes 31% mef(E)-positive, and 9% erm(B)-positive strains.

Conclusions
The dual-positive, multidrug-resistant S. pneumoniae clones have likely expanded by switching to non-vaccine serotypes after the heptavalent pneumococcal conjugate vaccine release, and their success limits therapy options. This upsurge could have a considerable clinical impact in Arizona.
DOI http://dx.doi.org/10.1186/1471-2180-12-12   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
Additional Notes This is an Open Access article distributed under the terms of the Creative Commons Attribution License 2.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Description for Link Link to CC Attribution 2.0 License
URL https://creativecommons.org/licenses/by/2.0/


© copyright

Every reasonable effort has been made to ensure that permission has been obtained for items included in CDU eSpace. If you believe that your rights have been infringed by this repository, please contact digitisation@cdu.edu.au.

 
Versions
Version Filter Type
Access Statistics: 33 Abstract Views, 29 File Downloads  -  Detailed Statistics
Created: Tue, 24 Feb 2015, 12:36:37 CST