Charles Darwin University

CDU eSpace
Institutional Repository

 
CDU Staff and Student only
 

Lewy bodies and neuronal loss in subcortical areas and disability in non-demented older people: A population based neuropathological cohort study

Byford, M., Brayne, C., McKeith, I., Chatfield, Mark, Ince, P. G., Matthews, F. E. and MRC CFAS Neuropathology group (2009). Lewy bodies and neuronal loss in subcortical areas and disability in non-demented older people: A population based neuropathological cohort study. BMC Geriatrics,9:1-9.

Document type: Journal Article
Attached Files (Some files may be inaccessible until you login with your CDU eSpace credentials)
Name Description MIMEType Size Downloads
Download this reading Chatfield_44322.pdf Published version application/pdf 233.07KB 25
Reading the attached file works best in Firefox, Chrome and IE 9 or later.

IRMA ID 75039815xPUB471
Title Lewy bodies and neuronal loss in subcortical areas and disability in non-demented older people: A population based neuropathological cohort study
Author Byford, M.
Brayne, C.
McKeith, I.
Chatfield, Mark
Ince, P. G.
Matthews, F. E.
MRC CFAS Neuropathology group
Journal Name BMC Geriatrics
Publication Date 2009
Volume Number 9
eISSN 1471-2318
Scopus ID 2-s2.0-68149162711
Start Page 1
End Page 9
Total Pages 9
Place of Publication United Kingdom
Publisher BioMed Central
HERDC Category C1 - Journal Article (DIISR)
Abstract Background
Functional disability, the loss of ability to carry out daily tasks unaided, is a major adverse outcome more common with increasing age. The potential contribution of neuropathological changes in subcortical areas of the brain associated with normal ageing may be a contributing factor to this loss of function. This study investigates the clinicopathological relationship between functional ability during life and pathological correlates identified at post mortem in an UK population of older people (66–102 years).  The aim is to examine the clinicopathological correlates of functional disability in subcortical neuronal populations of non-demented elderly individuals.

Methods
156 non-demented participants in the brain donation programme of the Medical Research Council Cognitive Function and Ageing Study (MRC-CFAS) were included in this study. Neuropathological examination was based on the CERAD protocol; pathologies of interest were amyloid plaques, neurofibrillary tangles, Lewy bodies, vascular disease and neuronal loss. Self-reported functional ability was scored according to a combined activities of daily living and instrumental activities of daily living scale.

Results
Functional disability was equally common in men and women over 65 years, and in both sexes disability was more common at older ages. Neuronal loss in several subcortical regions elevated the risk of functional disability by three-fold (95% CI 1.3–6.6). There was evidence for a relationship between Lewy bodies in the SN and functional disability.

Conclusion
Neuronal loss in subcortical regions is associated with functional disability in the older population. The causal relationships are not defined and require further investigation.
DOI http://dx.doi.org/10.1186/1471-2318-9-22   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
Additional Notes This is an Open Access article distributed under the terms of the Creative Commons Attribution License 2.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Description for Link Link to CC Attribution 2.0 License
URL https://creativecommons.org/licenses/by/2.0/


© copyright

Every reasonable effort has been made to ensure that permission has been obtained for items included in CDU eSpace. If you believe that your rights have been infringed by this repository, please contact digitisation@cdu.edu.au.

 
Versions
Version Filter Type
Access Statistics: 27 Abstract Views, 25 File Downloads  -  Detailed Statistics
Created: Tue, 24 Feb 2015, 12:36:39 CST