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Dietary fortificant iron intake is negatively associated with quality of life in patients with mildly active inflammatory bowel disease

Powell, Jonathan J., Cook, William B., Hutchinson, Carol, Tolkien, Zoe, Chatfield, Mark, Pereira, Dora I.A. and Lomer, Miranda C.E. (2013). Dietary fortificant iron intake is negatively associated with quality of life in patients with mildly active inflammatory bowel disease. Nutrition and Metabolism,10:1-8.

Document type: Journal Article
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IRMA ID 75039815xPUB498
Title Dietary fortificant iron intake is negatively associated with quality of life in patients with mildly active inflammatory bowel disease
Author Powell, Jonathan J.
Cook, William B.
Hutchinson, Carol
Tolkien, Zoe
Chatfield, Mark
Pereira, Dora I.A.
Lomer, Miranda C.E.
Journal Name Nutrition and Metabolism
Publication Date 2013
Volume Number 10
eISSN 1743-7075
Scopus ID 2-s2.0-84872148380
Start Page 1
End Page 8
Total Pages 8
Place of Publication United Kingdom
Publisher BioMed Central
HERDC Category C1 - Journal Article (DIISR)
Abstract Background
Iron deficiency anaemia and oral iron supplementation have been associated negatively with quality of life, and with adverse effects, respectively, in subjects with inflammatory bowel disease (IBD). Hence, the risk-benefit ratio of oral iron is not understood in this patient group. The present case–control study investigated whether dietary iron intake impacts on quality of life in IBD patients.

Methods
Quality of life, habitual dietary iron intakes and iron requirements were assessed in 29 patients with inactive or mildly active IBD as well as in 28 healthy control subjects.

Results
As expected, quality of life was worse in IBD patients as a whole in comparison to healthy controls according to EuroQol score and EuroQol VAS percentage (6.9 ± 1.6 vs 5.3 ± 0.6; p< 0.0001 and 77 ± 14% vs 88 ± 12%; p=0.004 respectively). For IBD subjects, 21/29 were iron deplete based upon serum iron responses to oral iron but, overall, were non-anaemic with mean haemoglobin of 13.3 ± 1.5 g/dL, and there was no difference in their quality of life compared to 8/29 iron replete subjects (Hb 14.0 ± 0.8 g/dL). Interestingly, total dietary iron intake was significantly negatively associated with quality of life in IBD patients, specifically for non-haem iron and, more specifically, for fortificant iron. Moreover, for total non-haem iron the negative association disappeared when fortificant iron values were subtracted. Finally, further sub-analysis indicated that the negative association between (fortificant) dietary iron intake and quality of life in IBD patients is driven by findings in patients with mildly active disease rather than in patients with quiescent disease.

Conclusions
Iron deficiency per se (i.e. without concomitant anaemia) does not appear to further affect quality of life in IBD patients with inactive or mildly active disease. However, in this preliminary study, dietary iron intake, particularly fortificant iron, appears to be significantly negatively associated with quality of life in patients with mildly active disease.
Keywords IDB
Iron intake
Iron deficiency
Quality of life
Fortificant iron
DOI http://dx.doi.org/10.1186/1743-7075-10-9   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
Additional Notes This is an Open Access article distributed under the terms of the Creative Commons Attribution License 2.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Description for Link Link to CC Attribution 2.0 License
URL https://creativecommons.org/licenses/by/2.0/


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