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Iron status is inversely associated with dietary iron intakes in patients with inactive or mildly active inflammatory bowel disease

Powell, Jonathan J., Cook, William B., Chatfield, Mark, Hutchinson, Carol, Pereira, Dora I. A. and Lomer, Miranda C. E. (2013). Iron status is inversely associated with dietary iron intakes in patients with inactive or mildly active inflammatory bowel disease. Nutrition and Metabolism,10:1-7.

Document type: Journal Article
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IRMA ID 75039815xPUB499
Title Iron status is inversely associated with dietary iron intakes in patients with inactive or mildly active inflammatory bowel disease
Author Powell, Jonathan J.
Cook, William B.
Chatfield, Mark
Hutchinson, Carol
Pereira, Dora I. A.
Lomer, Miranda C. E.
Journal Name Nutrition and Metabolism
Publication Date 2013
Volume Number 10
eISSN 1743-7075
Scopus ID 2-s2.0-84873029914
Start Page 1
End Page 7
Total Pages 7
Place of Publication United Kingdom
Publisher BioMed Central
HERDC Category C1 - Journal Article (DIISR)
Abstract Background
Patients with inflammatory bowel disease (IBD) frequently appear iron deplete but whether this is a reflection of dietary iron intakes is not known.

Methods
Dietary data were collected from 29 patients with inactive or mildly-active IBD and 28 healthy controls using a validated food frequency questionnaire that measured intakes of iron and its absorption modifiers. Non-haem iron availability was estimated using a recently developed algorithm. Subjects were classified for iron status based upon data from a concomitant and separately published study of iron absorption. Absorption was used to define iron status because haematological parameters are flawed in assessing iron status in inflammatory conditions such as IBD.

Results
Dietary intakes of total iron, non-haem iron and vitamin C were significantly greater in IBD patients who were iron replete compared to those who were iron deplete (by 48%, 48% and 94% respectively; p≤0.05). The predicted percentage of available non-haem iron did not differ between these groups (19.7 ± 2.0% vs 19.3 ± 2.0% respectively; p=0.25). However, because of the difference in iron intake, the overall amount of absorbed iron did (2.4 ± 0.8 mg/d vs 1.7 ± 0.5 mg/d; p=0.013). No such differences were observed in the healthy control subjects.

Conclusions
In IBD, iron status is more closely related to the quality and quantity of dietary iron intake than in the general healthy population.

Keywords IBD
Iron deficiency anaemia
Iron intake
Diet
Food frequency questionnaire
DOI http://dx.doi.org/10.1186/1743-7075-10-18   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
Additional Notes This is an Open Access article distributed under the terms of the Creative Commons Attribution License 2.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Description for Link Link to CC Attribution 2.0 License
URL https://creativecommons.org/licenses/by/2.0/


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