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Bupropion overdose: QTc prolongation and its clinical significance

Isbister, GK and Balit, CR (2003). Bupropion overdose: QTc prolongation and its clinical significance. Annals of Pharmacotherapy,37(7-8):999-1002.

Document type: Journal Article
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Title Bupropion overdose: QTc prolongation and its clinical significance
Author Isbister, GK
Balit, CR
Journal Name Annals of Pharmacotherapy
Publication Date 2003
Volume Number 37
Issue Number 7-8
ISSN 1542-6270   (check CDU catalogue open catalogue search in new window)
Start Page 999
End Page 1002
Total Pages 4
Place of Publication US
Publisher Harvey Whitney Books Company
Field of Research 1115 - Pharmacology and Pharmaceutical Sciences
HERDC Category C1 - Journal Article (DEST)
Abstract OBJECTIVE: To investigate the cardiotoxicity of bupropion hydrochloride in deliberate self-poisoning. METHODS: A prospective study was conducted in a national poisons information center (PIC) of cases of adult deliberate self-poisoning with medical record follow-up of the patients. Fifty-nine cases of bupropion deliberate self-poisoning managed in the hospital, in which the New South Wales PIC was contacted for advice, were evaluated from November 2000 through July 2001. Clinical effects and electrocardiographic (ECG) parameters (QRS, QT, QTc) were the main outcome measures. RESULTS: ECGs were available for 17 of the 59 patients for analysis, 9 patients (53%) were women, and median patient age was 28 years (interquartile range 22-37). The mean +/- SD ingested bupropion dose was 3.8 +/- 3.1 g. Tachycardia occurred in 13 patients (76%; 95% CI 50 to 93) and hypertension in 8 patients (47%). There were no reports of hypotension or arrhythmias. There was a significantly increased QTc of 461 +/- 34 msec in the patients with bupropion overdose compared with previously developed controls; 13 of the 17 cases had a QTc
Keywords Bupropion
cardiotoxicity
clinical
overdose
Pharmacotherapy
DOI http://dx.doi.org/10.1345/aph.1C481   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
Additional Notes 3747 (Journal) DA - 20030704IS - 1060-0280 (Print)LA - engPT - Clinical TrialPT - Journal ArticleRN - 0 (Antidepressive Agents, Second-Generation)RN - 0 (Delayed-Action Preparations)RN - 34841-39-9 (Bupropion)SB - IM
 
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Created: Mon, 17 Dec 2007, 09:02:11 CST