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The number needed to vaccinate (NNV) and population extensions of the NNV: comparison of influenza and pneumococcal vaccine programmes for people aged 65 years and over

Kelly, Heath, Attia, John, Andrews, Ross M. and Heller, Richard F. (2004). The number needed to vaccinate (NNV) and population extensions of the NNV: comparison of influenza and pneumococcal vaccine programmes for people aged 65 years and over. Vaccine,22(17-18):2192-2198.

Document type: Journal Article
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Title The number needed to vaccinate (NNV) and population extensions of the NNV: comparison of influenza and pneumococcal vaccine programmes for people aged 65 years and over
Author Kelly, Heath
Attia, John
Andrews, Ross M.
Heller, Richard F.
Journal Name Vaccine
Publication Date 2004
Volume Number 22
Issue Number 17-18
ISSN 0264-410X   (check CDU catalogue  open catalogue search in new window)
Start Page 2192
End Page 2198
Total Pages 7
Place of Publication United Kingdom
Publisher Elsevier Ltd
Field of Research 0699 - Other Biological Sciences
0799 - Other Agricultural and Veterinary Sciences
1107 - Immunology
HERDC Category C1 - Journal Article (DEST)
Abstract The number needed to treat (NNT) and population extensions of the NNT describe the population outcomes of disease treatment, usually for chronic diseases. We have developed similar measures for vaccine preventable diseases based on the number needed to vaccinate. These measures quantify the number of people, or the number of vaccine doses, needed to prevent one event due to disease per year and allow the calculation of the vaccine cost to prevent one event due to disease per year. We used this method to compare influenza and pneumococcal vaccine programmes for people aged 65 years or more. We calculated the vaccine cost (dollars AUD) to prevent a case of disease, a hospitalisation or a death due to influenza or invasive pneumococcal disease each year in this age group. For influenza, the vaccine costs were dollars 598 to prevent one case per year, dollars 10787 per hospitalisation prevented and dollars 74801 per death prevented each year. We assumed all cases of invasive pneumococcal disease were hospitalised so the vaccine cost of dollars 11494 per case prevented was the same as the vaccine cost per hospitalisation prevented, while the vaccine cost per death prevented each year was dollars 49972. These results suggest the vaccine costs for the prevention of one hospitalisation or one death each year due to invasive pneumococcal disease among the elderly in Australia would be similar to the costs for the prevention of one hospitalisation or death due to influenza.
Keywords influenza
population
pneumococcal
vaccine
DOI http://dx.doi.org/10.1016/j.vaccine.2003.11.052   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
Additional Notes 3637 (Journal) DA - 20040519IS - 0264-410X (Print)LA - engPT - Comparative StudyPT - Journal ArticlePT - Research Support, Non-U.S. Gov'tRN - 0 (Influenza Vaccines)RN - 0 (Pneumococcal Vaccines)SB - IM
 
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Created: Mon, 17 Dec 2007, 09:02:11 CST