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Non-encapsulated Haemophilus influenzae in Aboriginal infants with otitis media : Prolonged carriage of P2 porin variants and evidence for horizontal P2 gene transfer

Smith-Vaughan, Heidi C., Sriprakash, Kadaba S., Mathews, John D. and Kemp, David J. (1997). Non-encapsulated Haemophilus influenzae in Aboriginal infants with otitis media : Prolonged carriage of P2 porin variants and evidence for horizontal P2 gene transfer. Infection and Immunity,65(4):1468-1474.

Document type: Journal Article
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Title Non-encapsulated Haemophilus influenzae in Aboriginal infants with otitis media : Prolonged carriage of P2 porin variants and evidence for horizontal P2 gene transfer
Author Smith-Vaughan, Heidi C.
Sriprakash, Kadaba S.
Mathews, John D.
Kemp, David J.
Journal Name Infection and Immunity
Publication Date 1997
Volume Number 65
Issue Number 4
ISSN 1098-5522   (check CDU catalogue  open catalogue search in new window)
Start Page 1468
End Page 1474
Total Pages 7
Place of Publication Washington, United States
Publisher American Society for Microbiology
Language English
Field of Research 320000 Medical and Health Sciences
Abstract Aboriginal infants in the Northern Territory of Australia experience recurrent otitis media from an early age. Nonencapsulated Haemophilus influenzae (NCHi) colonization of the nasopharynx initially occurs within weeks of birth, persists throughout infancy and most of childhood, and contributes to otitis media. We established previously that the high carriage rates of NCHi in these infants result from concurrent and successive colonization with multiple strains, with sequential elimination of dominant strains. We have now sequenced loops 4, 5, and 6 of the NCHi P2 porin gene and characterized several strains with prolonged carriage times. Furthermore, despite a wide diversity of P2 gene sequences, we have four examples of P2 gene identity for strains with different genetic backgrounds as characterized by PCR ribotyping and randomly amplified polymorphic DNA typing, which leads us to suggest that the P2 gene has been transferred between strains. We also discuss the possibility that the paradoxical observation of cocolonization and prolonged carriage of P2-identical strains is related to immune suppression or tolerance in the host.
Keywords Aboriginal
Haemophilus influenzae
Infant
Gene transfer
otitis media
porin variants
Additional Notes Copyright by the American Society for Microbiology
Description for Link Link to published version
URL http://iai.asm.org/content/65/4/1468.abstract


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