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Low genetic diversity of Haemophilus influenzae type b compared to nonencapsulated H. influenzae in a population in which H. influenzae is highly endemic

Smith-Vaughan, Heidi C., Sriprakash, Kadaba S., Leach, Amanda J., Mathews, John D. and Kemp, David J. (1998). Low genetic diversity of Haemophilus influenzae type b compared to nonencapsulated H. influenzae in a population in which H. influenzae is highly endemic. Infection and Immunity,66(7):3403-3409.

Document type: Journal Article
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Title Low genetic diversity of Haemophilus influenzae type b compared to nonencapsulated H. influenzae in a population in which H. influenzae is highly endemic
Author Smith-Vaughan, Heidi C.
Sriprakash, Kadaba S.
Leach, Amanda J.
Mathews, John D.
Kemp, David J.
Journal Name Infection and Immunity
Publication Date 1998
Volume Number 66
Issue Number 7
ISSN 1098-5522   (check CDU catalogue  open catalogue search in new window)
Start Page 3403
End Page 3409
Total Pages 7
Place of Publication USA
Publisher American Society for Microbiology
Language English
Field of Research 320000 Medical and Health Sciences
Abstract Immunization with Haemophilus influenzae type b (Hib) conjugate polysaccharide vaccines has dramatically reduced Hib disease worldwide. As in other populations, nasopharyngeal carriage of Hib declined markedly in Aboriginal infants following vaccination, although carriage has not been entirely eliminated. In this study, we describe the genetic characteristics and the carriage dynamics of longitudinal isolates of Hib, characterized by using several typing methods. In addition, carriage rates of nonencapsulated H. influenzae (NCHi) are high, and concurrent colonization with Hib and NCHi is common; we also observed NCHi isolates which were genetically similar to Hib. There is a continuing need to promote Hib immunization and monitor H. influenzae carriage in populations in which the organism is highly endemic, not least because of the possibility of genetic exchange between Hib and NCHi strains in such populations.
Keywords Haemophilus influenzae type b
nonencapsulated H. influenzae
Population
Additional Notes 4379 (Journal)
Description for Link Link to Article
URL http://iai.asm.org/cgi/reprint/66/7/3403?maxtoshow=&hits=10&RESULTFORMAT=1&andorexacttitle=and&andorexacttitleabs=and&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&volume=66&firstpage=3403&resourcetype=HWCIT
 
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