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Preexisting CD8+ T-cell immunity to the H7N9 influenza A virus varies across ethnicities

Quinones-Parra, Sergio, Grant, Emma, Loh, Liyen, Nguyen, Thi H.O., Campbell, Kristy-Anne, Tong, Steven Y. C., Miller, Adrian, Doherty, Peter C., Vijaykrishna, Dhanasekaran, Rossjohn, Jamie, Gras, Stephanie and Kedzierska, Katherine (2014). Preexisting CD8+ T-cell immunity to the H7N9 influenza A virus varies across ethnicities. Proceedings of the National Academy of Sciences of USA,111(3):1049-1054.

Document type: Journal Article
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IRMA ID 11436xPUB60
Title Preexisting CD8+ T-cell immunity to the H7N9 influenza A virus varies across ethnicities
Author Quinones-Parra, Sergio
Grant, Emma
Loh, Liyen
Nguyen, Thi H.O.
Campbell, Kristy-Anne
Tong, Steven Y. C.
Miller, Adrian
Doherty, Peter C.
Vijaykrishna, Dhanasekaran
Rossjohn, Jamie
Gras, Stephanie
Kedzierska, Katherine
Journal Name Proceedings of the National Academy of Sciences of USA
Publication Date 2014
Volume Number 111
Issue Number 3
ISSN 0027-8424   (check CDU catalogue open catalogue search in new window)
Scopus ID 2-s2.0-84892914586
Start Page 1049
End Page 1054
Total Pages 6
Place of Publication United States of America
Publisher National Academy of Sciences
HERDC Category C1 - Journal Article (DIISR)
Abstract The absence of preexisting neutralizing antibodies specific for the novel A (H7N9) influenza virus indicates a lack of prior human exposure. As influenza A virus–specific CD8+ T lymphocytes (CTLs) can be broadly cross-reactive, we tested whether immunogenic peptides derived from H7N9 might be recognized by memory CTLs established following infection with other influenza strains. Probing across multiple ethnicities, we identified 32 conserved epitopes derived from the nucleoprotein (NP) and matrix-1 (M1) proteins. These NP and M1 peptides are presented by HLAs prevalent in 16–57% of individuals. Remarkably, some HLA alleles (A*0201, A*0301, B*5701, B*1801, and B*0801) elicit robust CTL responses against any human influenza A virus, including H7N9, whereas ethnicities where HLA-A*0101, A*6801, B*1501, and A*2402 are prominent, show limited CTL response profiles. By this criterion, some groups, especially the Alaskan and Australian Indigenous peoples, would be particularly vulnerable to H7N9 infection. This dissection of CTL-mediated immunity to H7N9 thus suggests strategies for both vaccine delivery and development.
DOI http://dx.doi.org/10.1073/pnas.1322229111   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
Description for Link Link to publisher's version
URL http://www.pnas.org/content/111/3/1049.abstract
 
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