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Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria

White, Nicholas, Ashley, Elizabeth, Nosten, François, Delves, Michael, Ruecker, Andrea, Smithuis, Frank, Eziefula, Chi, Bousema, Teun, Drakeley, Chris, Chotivanich, Kesinee, Imwong, Mallika, Pukrittayakamee, S, Prachumsri, Jetsumon, Chu, Cindy, Andolina, Chiara, Bancone, Germana, Hien, Tran, Mayxay, Mayfong, Taylor, Walter and Price, Ric (2014). Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria. Malaria Journal,13(1 - Article No. 483).

Document type: Journal Article
Citation counts: Altmetric Score Altmetric Score is 15
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IRMA ID 11381xPUB36
Title Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria
Author White, Nicholas
Ashley, Elizabeth
Nosten, François
Delves, Michael
Ruecker, Andrea
Smithuis, Frank
Eziefula, Chi
Bousema, Teun
Drakeley, Chris
Chotivanich, Kesinee
Imwong, Mallika
Pukrittayakamee, S
Prachumsri, Jetsumon
Chu, Cindy
Andolina, Chiara
Bancone, Germana
Hien, Tran
Mayxay, Mayfong
Taylor, Walter
Price, Ric
Journal Name Malaria Journal
Publication Date 2014
Volume Number 13
Issue Number 1 - Article No. 483
ISSN 1475-2875   (check CDU catalogue open catalogue search in new window)
Total Pages 13
Place of Publication United Kingdom
Publisher BioMed Central Ltd.
HERDC Category C1 - Journal Article (DIISR)
Abstract Indirect clinical measures assessing anti-malarial drug transmission-blocking activity in falciparum malaria include
measurement of the duration of gametocytaemia, the rate of gametocyte clearance or the area under the
gametocytaemia-time curve (AUC). These may provide useful comparative information, but they underestimate
dose-response relationships for transmission-blocking activity. Following 8-aminoquinoline administration P. falciparum
gametocytes are sterilized within hours, whereas clearance from blood takes days. Gametocytaemia AUC and clearance
times are determined predominantly by the more numerous female gametocytes, which are generally less drug
sensitive than the minority male gametocytes, whereas transmission-blocking activity and thus infectivity is determined
by the more sensitive male forms. In choosing doses of transmission-blocking drugs there is no substitute yet for
mosquito-feeding studies.
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