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Liver transplantation for the treatment of homozygous familial hypercholesterolaemia in an era of emerging lipid-lowering therapies

Page, M. M., Ekinci, Elif I., Jones, R. M., Angus, P. W., Gow, P. J. and O'Brien, R. C. (2014). Liver transplantation for the treatment of homozygous familial hypercholesterolaemia in an era of emerging lipid-lowering therapies. Internal Medicine Journal,44(6):601-604.

Document type: Journal Article
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IRMA ID 11436xPUB15
Title Liver transplantation for the treatment of homozygous familial hypercholesterolaemia in an era of emerging lipid-lowering therapies
Author Page, M. M.
Ekinci, Elif I.
Jones, R. M.
Angus, P. W.
Gow, P. J.
O'Brien, R. C.
Journal Name Internal Medicine Journal
Publication Date 2014
Volume Number 44
Issue Number 6
ISSN 1444-0903   (check CDU catalogue open catalogue search in new window)
Scopus ID 2-s2.0-84904642201
Start Page 601
End Page 604
Total Pages 4
Place of Publication Australia
Publisher Wiley-Blackwell Publishing Asia
HERDC Category C1 - Journal Article (DIISR)
Abstract Homozygous familial hypercholesterolaemia (FH) causes severe premature coronary artery disease because of very high levels of low density lipoprotein (LDL)-cholesterol. Standard lipid-lowering drugs and LDL-apheresis may not be sufficiently effective. Liver transplantation replaces defective LDL receptors and vastly improves the lipid profile, and we present the first report of an Australian adult to receive this treatment. Emerging drug treatments for FH may be alternatives to LDL-apheresis and transplantation, but long-term safety and efficacy data are lacking for all of these options.
Keywords familial hypercholesterolaemia
liver transplantation
LDL-apheresis
mipomersen
lomitapide
DOI http://dx.doi.org/10.1111/imj.12444   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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