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Variable virulence factors in Burkholderia pseudomallei (Melioidosis) associated with human disease

Sarovich, Derek S., Price, Erin P., Webb, Jessica R., Ward, Linda M., Voutsinos, Marcos, Tuanyok, Apichai, Mayo, Mark J., Kaestli, Mirjam E. and Currie, Bart J. (2014). Variable virulence factors in Burkholderia pseudomallei (Melioidosis) associated with human disease. PLoS One,9(3 - Article No. e91682).

Document type: Journal Article
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IRMA ID 11436xPUB19
NHMRC Grant No. 605820
Title Variable virulence factors in Burkholderia pseudomallei (Melioidosis) associated with human disease
Author Sarovich, Derek S.
Price, Erin P.
Webb, Jessica R.
Ward, Linda M.
Voutsinos, Marcos
Tuanyok, Apichai
Mayo, Mark J.
Kaestli, Mirjam E.
Currie, Bart J.
Journal Name PLoS One
Publication Date 2014
Volume Number 9
Issue Number 3 - Article No. e91682
ISSN 1932-6203   (check CDU catalogue open catalogue search in new window)
Scopus ID 2-s2.0-84897532697
Total Pages 4
Place of Publication United States of America
Publisher Public Library of Science
HERDC Category C1 - Journal Article (DIISR)
Abstract Burkholderia pseudomallei is a Gram-negative environmental bacterium that causes melioidosis, a potentially life-threatening infectious disease affecting mammals, including humans. Melioidosis symptoms are both protean and diverse, ranging from mild, localized skin infections to more severe and often fatal presentations including pneumonia, septic shock with multiple internal abscesses and occasionally neurological involvement. Several ubiquitous virulence determinants in B. pseudomallei have already been discovered. However, the molecular basis for differential pathogenesis has, until now, remained elusive. Using clinical data from 556 Australian melioidosis cases spanning more than 20 years, we identified a Burkholderia mallei-like actin polymerization bimABm gene that is strongly associated with neurological disease. We also report that a filamentous hemagglutinin gene, fhaB3, is associated with positive blood cultures but is negatively correlated with localized skin lesions without sepsis. We show, for the first time, that variably present virulence factors play an important role in the pathogenesis of melioidosis. Collectively, our study provides a framework for assessing other non-ubiquitous bacterial virulence factors and their association with disease, such as candidate loci identified from large-scale microbial genome-wide association studies.
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