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Prospective Characterization of Protracted Bacterial Bronchitis in hildren

Wurzel, Danielle F., Marchant, Julie M., Yerkovich, Stephanie, Upham, John W., Mackay, Ian M., Masters, Ian B. and Chang, Anne B. (2014). Prospective Characterization of Protracted Bacterial Bronchitis in hildren. Chest,145(6):1271-1278.

Document type: Journal Article
Citation counts: Altmetric Score Altmetric Score is 8
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IRMA ID 11436xPUB2
Title Prospective Characterization of Protracted Bacterial Bronchitis in hildren
Author Wurzel, Danielle F.
Marchant, Julie M.
Yerkovich, Stephanie
Upham, John W.
Mackay, Ian M.
Masters, Ian B.
Chang, Anne B.
Journal Name Chest
Publication Date 2014
Volume Number 145
Issue Number 6
ISSN 0012-3692   (check CDU catalogue open catalogue search in new window)
Scopus ID 2-s2.0-84899806237
Start Page 1271
End Page 1278
Total Pages 8
Place of Publication United States of America
Publisher American College of Chest Physicians
HERDC Category C1 - Journal Article (DIISR)
Abstract
Background:
Prior studies on protracted bacterial bronchitis (PBB) in children have been retrospective or based on small cohorts. As PBB shares common features with other pediatric conditions, further characterization is needed to improve diagnostic accuracy among clinicians. In this study, we aim to further delineate the clinical and laboratory features of PBB in a larger cohort, with a specific focus on concurrent viral detection.
Methods: Children with and without PBB (control subjects) undergoing flexible bronchoscopy were prospectively recruited. Basic immune function testing and lymphocyte subset analyses were performed. BAL specimens were processed for cellularity and microbiology. Viruses were identified using polymerase chain reaction (PCR) and bacteria were identified via culture.
Results: The median age of the 104 children (69% male) with PBB was 19 months (interquartile range [IQR], 12-30 mo). Compared with control subjects, children with PBB were more likely to have attended childcare (OR, 8.43; 95% CI, 2.34-30.46). High rates of wheeze were present in both groups, and tracheobronchomalacia was common. Children with PBB had significantly elevated percentages of neutrophils in the lower airways compared with control subjects, and adenovirus was more likely to be detected in BAL specimens in those with PBB (OR, 6.69; 95% CI, 1.50-29.80). Median CD56 and CD16 natural killer (NK) cell levels in blood were elevated for age in children with PBB (0.7 × 109/L; IQR, 0.5-0.9 cells/L).
Conclusions:
Children with PBB are, typically, very young boys with prolonged wet cough and parent-reported wheeze who have attended childcare. Coupled with elevated NK-cell levels, the association between adenovirus and PBB suggests a likely role of viruses in PBB pathogenesis.

DOI http://dx.doi.org/10.1378/chest.13-2442   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
Description for Link Link to publisher's version
URL http://journal.publications.chestnet.org/article.aspx?articleid=1814537
 
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