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HPV genotype prevalence in Australian women undergoing routine cervical screening by cytology status prior to implementation of an HPV vaccination program

Tabrizi, Sepehr N., Brotherton, Julia M. L., Stevens, Matthew, Condon, John R., McIntyre, Peter, Smith, David and Garland, Suzanne M. (2014). HPV genotype prevalence in Australian women undergoing routine cervical screening by cytology status prior to implementation of an HPV vaccination program. Journal of Clinical Virology,60(3):250-256.

Document type: Journal Article
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IRMA ID 11436xPUB24
Title HPV genotype prevalence in Australian women undergoing routine cervical screening by cytology status prior to implementation of an HPV vaccination program
Author Tabrizi, Sepehr N.
Brotherton, Julia M. L.
Stevens, Matthew
Condon, John R.
McIntyre, Peter
Smith, David
Garland, Suzanne M.
Journal Name Journal of Clinical Virology
Publication Date 2014
Volume Number 60
Issue Number 3
ISSN 1386-6532   (check CDU catalogue open catalogue search in new window)
Scopus ID 2-s2.0-84902126358
Start Page 250
End Page 256
Total Pages 7
Place of Publication Netherlands
Publisher Elsevier BV
HERDC Category C1 - Journal Article (DIISR)
Abstract Background
Data on the prevalence of cervical HPV genotypes in Australia by age and by grade of cytological abnormality are sparse.

Objective

Measure prevalence of HPV genotypes among 2620 Australian women by age and cytology status.

Study design
Women presenting for routine Pap smear screening were recruited from diverse regions, including a significant sample of Indigenous women. DNA extracts prepared from Thinprep specimens were HPV genotyped by Roche LINEAR ARRAY HPV.

Results

HPV prevalence and genotype distribution were stratified by age (mean 32.6 y) and Pap smear result (cytology normal in 86.7%). Overall HPV prevalence was 38.7% with high-risk HPV prevalence of 26.5%. Prevalence of HPV (66.3% in women < 21 y to 15.3% in women > 40 y), multiple HPV infection (45.5% in <21 y to 5.8% in >40 y) and vaccine-targeted genotypes (HPV 6/11/16/18) (34.1% in <21 y to 2.4% in >40 y) declined significantly with age. The six most common genotypes were: HPV 16 (8.3%), 51 (5.1%), 53 (4.7%), 62 (4.3%), 89 (3.9%) and 52 (3.8%). HR-HPV prevalence increased from 21.1% in women with normal cytology to 80.9% in those with cytologically predicted high-grade abnormalities (HGAs) (p < 0.001). The most common genotypes in women with HGAs were HPV 16 (51.1%), 18 (14.9%), 52 (12.8%), 31 (10.6%), and 33 (10.6%): all HR-types.

Conclusion

Pre-vaccination cross-sectional prevalence of HR-HPV infection was high in this sample of Australian women attending for screening. HPV 16 was the commonest high-risk type detected at all ages and cytological grades.
Keywords Human papillomavirus
Genotype
Cervical cytology
Cervical Cancer
CIN
Linear array
DOI http://dx.doi.org/10.1016/j.jcv.2014.04.013   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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