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An evaluation of the indirect cohort method to estimate the effectiveness of the pneumococcal polysaccharide vaccine

Moberley, Sarah A. and Andrews, Ross M. (2014). An evaluation of the indirect cohort method to estimate the effectiveness of the pneumococcal polysaccharide vaccine. Journal of Vaccines & Immunization,2(1):4-6.

Document type: Journal Article
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IRMA ID 11436xPUB4
Title An evaluation of the indirect cohort method to estimate the effectiveness of the pneumococcal polysaccharide vaccine
Author Moberley, Sarah A.
Andrews, Ross M.
Journal Name Journal of Vaccines & Immunization
Publication Date 2014
Volume Number 2
Issue Number 1
ISSN 2053-1273   (check CDU catalogue  open catalogue search in new window)
Start Page 4
End Page 6
Total Pages 3
Place of Publication United Kingdom
Publisher NobleResearch Publishers Ltd.
HERDC Category C1 - Journal Article (DIISR)
Abstract We examined the validity of the indirect cohort method as a rapid assessment tool to estimate pneumococcal polysaccharide vaccine effectiveness (VE). Using evidence from published clinical trials, we reviewed the primary assumption about the appropriateness of the control group underpinning the indirect cohort method, which is that the risk of non-vaccine type invasive pneumococcal disease is equal for vaccinated and unvaccinated participants. We found an absence of evidence to support the non-differential risk assumption for non-vaccine type invasive pneumococcal disease occurring among clinical trial participants. In those instances where the design has been utilised, we also note that these typically rely on very small numbers of non-vaccine type invasive pneumococcal disease adding to the concerns as an unreliable comparator. We do not consider the indirect cohort method to be a valid tool for rapid assessment of pneumococcal polysaccharide VE.
Keywords Indirect cohort method
Pneumococcal polysaccharide vaccine
Vaccine effectiveness
Pneumococcal disease
DOI http://dx.doi.org/10.14312/2053-1273.2014-1   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
Description for Link Link to publisher's version
URL http://nobleresearch.org/Doi/10.14312/2053-1273.2014-1
 
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Created: Wed, 19 Aug 2015, 12:11:59 CST