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Current antimicrobial susceptibility of first-episode melioidosis Burkholderia pseudomallei isolates from the Northern Territory, Australia

Crowe, Amy, McMahon, Nicole, Currie, Bart J. and Baird, Robert W. (2014). Current antimicrobial susceptibility of first-episode melioidosis Burkholderia pseudomallei isolates from the Northern Territory, Australia. International Journal of Antimicrobial Agents,44(2):160-162.

Document type: Journal Article
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IRMA ID 11436xPUB56
Title Current antimicrobial susceptibility of first-episode melioidosis Burkholderia pseudomallei isolates from the Northern Territory, Australia
Author Crowe, Amy
McMahon, Nicole
Currie, Bart J.
Baird, Robert W.
Journal Name International Journal of Antimicrobial Agents
Publication Date 2014
Volume Number 44
Issue Number 2
ISSN 0924-8579   (check CDU catalogue open catalogue search in new window)
Scopus ID 2-s2.0-84905564512
Start Page 160
End Page 162
Total Pages 3
Place of Publication Netherlands
Publisher Elsevier BV
HERDC Category C1 - Journal Article (DIISR)
Abstract Burkholderia pseudomallei is a saprophytic Gram-negative bacterium responsible for the tropical infectious disease melioidosis. Melioidosis is endemic to northern Australia and Southeast Asia. In this study, 234 isolates of B. pseudomallei obtained from the first positive clinical specimen from 234 consecutive patients diagnosed with melioidosis between October 2009 and September 2012 were reviewed. All isolates were susceptible to meropenem and ceftazidime. In total, 226 isolates (96.6%) were susceptible to doxycycline and 232 (99.1%) were susceptible to trimethoprim/sulfamethoxazole (TMP/SMX; co-trimoxazole). Primary resistance of B. pseudomallei to ceftazidime and/or meropenem is exceedingly rare and clinicians can be confident in the current treatment guidelines for melioidosis. Whether the very low rates of TMP/SMX resistance seen in Australia reflect the global situation requires further studies using Etest, especially to clarify the rate of resistance in Thailand.
Keywords Burkholderia pseudomallei
Melioidosis
Antimicrobial susceptibility
DOI http://dx.doi.org/10.1016/j.ijantimicag.2014.04.012   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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