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Adenovirus species C is associated with chronic suppurative lung diseases in children

Wurzel, Danielle F., Mackay, Ian M., Marchant, Julie M., Wang, Claire Y. T., Yerkovich, Stephanie T., Upham, John W., Smith-Vaughan, Heidi C., Petsky, Helen L. and Chang, Anne B. (2014). Adenovirus species C is associated with chronic suppurative lung diseases in children. Clinical Infectious Diseases,59(1):34-40.

Document type: Journal Article
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IRMA ID 75039815xPUB254
Title Adenovirus species C is associated with chronic suppurative lung diseases in children
Author Wurzel, Danielle F.
Mackay, Ian M.
Marchant, Julie M.
Wang, Claire Y. T.
Yerkovich, Stephanie T.
Upham, John W.
Smith-Vaughan, Heidi C.
Petsky, Helen L.
Chang, Anne B.
Journal Name Clinical Infectious Diseases
Publication Date 2014
Volume Number 59
Issue Number 1
ISSN 1058-4838   (check CDU catalogue open catalogue search in new window)
Scopus ID 2-s2.0-84903971424
Start Page 34
End Page 40
Total Pages 7
Place of Publication United States
Publisher Oxford University Press
HERDC Category C1 - Journal Article (DIISR)
Abstract Background. The role of human adenoviruses (HAdVs) in chronic respiratory disease pathogenesis is recognized. However, no studies have performed molecular sequencing of HAdVs from the lower airways of children with chronic endobronchial suppuration. We thus examined the major HAdV genotypes/species, and relationships to bacterial coinfection, in children with protracted bacterial bronchitis (PBB) and mild bronchiectasis (BE).

Methods. Bronchoalveolar lavage (BAL) samples of 245 children with PBB or mild (cylindrical) BE were included in this prospective cohort study. HAdVs were genotyped (when possible) in those whose BAL had HAdV detected (HAdV+). Presence of bacterial infection (defined as ≥104 colony-forming units/mL) was compared between BAL HAdV+ and HAdV negative (HAdV−) groups. Immune function tests were performed including blood lymphocyte subsets in a random subgroup.

Results. Species C HAdVs were identified in 23 of 24 (96%) HAdV+ children; 13 (57%) were HAdV-1 and 10 (43%) were HAdV-2. An HAdV+ BAL was significantly associated with bacterial coinfection with Haemophilus influenzae, Moraxella catarrhalis, or Streptococcus pneumoniae (odds ratio [OR], 3.27; 95% confidence interval, 1.38–7.75; P = .007) and negatively associated with Staphylococcus aureus infection (P = .03). Young age was related to increased rates of HAdV+. Blood CD16 and CD56 natural killer cells were significantly more likely to be elevated in those with HAdV (80%) compared with those without (56.1%) (P = .027).

Conclusions. HAdV-C is the major HAdV species detected in the lower airways of children with PBB and BE. Younger age appears to be an important risk factor for HAdV+ of the lower airways and influences the likelihood of bacterial coinfection.
Keywords bronchiectasis
protracted bacterial bronchitis
respiratory bacteria
respiratory viruses
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