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Associations between periodontal disease and cardiovascular surrogate measures among Indigenous Australians

Kapellas, Kostas, Jamieson, Lisa M., Do, Loc G., Bartold, P. Mark, Wang, Hao, Maple-Brown, Louise J., Sullivan, David, O'Dea, Kerin, Brown, Alex, Celermajer, David S., Slade, Gary D. and Skilton, Michael R. (2014). Associations between periodontal disease and cardiovascular surrogate measures among Indigenous Australians. International Journal of Cardiology,173(2):190-196.

Document type: Journal Article
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IRMA ID 75039815xPUB260
Title Associations between periodontal disease and cardiovascular surrogate measures among Indigenous Australians
Author Kapellas, Kostas
Jamieson, Lisa M.
Do, Loc G.
Bartold, P. Mark
Wang, Hao
Maple-Brown, Louise J.
Sullivan, David
O'Dea, Kerin
Brown, Alex
Celermajer, David S.
Slade, Gary D.
Skilton, Michael R.
Journal Name International Journal of Cardiology
Publication Date 2014
Volume Number 173
Issue Number 2
ISSN 0167-5273   (check CDU catalogue open catalogue search in new window)
Scopus ID 2-s2.0-84898894935
Start Page 190
End Page 196
Total Pages 7
Place of Publication Ireland
Publisher Elsevier Ireland Ltd.
HERDC Category C1 - Journal Article (DIISR)
Abstract Background/objectives
Inflammation is a key pathogenetic factor in atherogenesis. Periodontitis is a chronic inflammatory source which can have systemic impacts. Indigenous Australians have a higher prevalence of periodontal disease and experience cardiovascular disease earlier than non-Indigenous Australians. The aim was to describe the association between severity of periodontal inflammatory disease and measures of arterial structure and function.

Methods

Periodontal disease in a convenience sample of Indigenous Australians was assessed clinically; for those with periodontal disease, the extent of periodontal pockets ≥ 4 mm was stratified into quartiles. Vascular health was measured non-invasively via carotid-dorsalis pedis pulse-wave velocity (PWV), and via B-mode ultrasound of the common carotid intima-media (IMT). Non-fasting blood samples were collected for lipid and inflammatory marker evaluation. Linear regression models were constructed to determine the associations between extent of periodontal pocketing and vascular health, adjusting for traditional cardiovascular common risk factors.

Results

273 Indigenous Australian adults were recruited and complete data was available for 269 participants (154 males), median age 39 years. Arterial stiffness (PWV) significantly increased with increasing extent of periodontal pocketing (p trend = 0.001). By contrast, carotid IMT did not differ across quartiles.

Conclusions

Periodontal pocketing was associated with central arterial stiffness, a marker of presymptomatic arterial dysfunction, in Indigenous Australian adults with periodontal disease.
Keywords Arterial stiffening
Aboriginal
Periodontal disease
Type 2 diabetes
Smoking
DOI http://dx.doi.org/10.1016/j.ijcard.2014.02.015   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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Created: Wed, 19 Aug 2015, 12:13:43 CST