Charles Darwin University

CDU eSpace
Institutional Repository

 
CDU Staff and Student only
 

Comparison of Anti-pneumococcal Antibodies in Cord Blood From Australian Indigenous and Gambian Neonates and the Implications for Otitis Media

Balloch, Anne, Licciardi, Paul V., Kemp, Andrew, Leach, Amanda J., Mulholland, E. Kim and Tang, Mimi (2014). Comparison of Anti-pneumococcal Antibodies in Cord Blood From Australian Indigenous and Gambian Neonates and the Implications for Otitis Media. The Pediatric Infectious Disease Journal,33(4):e116-e120.

Document type: Journal Article
Citation counts: Altmetric Score Altmetric Score is 1
Google Scholar Search Google Scholar

IRMA ID 75039815xPUB270
Title Comparison of Anti-pneumococcal Antibodies in Cord Blood From Australian Indigenous and Gambian Neonates and the Implications for Otitis Media
Author Balloch, Anne
Licciardi, Paul V.
Kemp, Andrew
Leach, Amanda J.
Mulholland, E. Kim
Tang, Mimi
Journal Name The Pediatric Infectious Disease Journal
Publication Date 2014
Volume Number 33
Issue Number 4
ISSN 0891-3668   (check CDU catalogue open catalogue search in new window)
Start Page e116
End Page e120
Total Pages 5
Place of Publication United States
Publisher Lippincott Williams & Wilkins
HERDC Category C1 - Journal Article (DIISR)
Abstract Background: Australian indigenous infants experience the highest incidence of chronic suppurative and acute otitis media in the world with many babies developing disease in the early postnatal period. Streptococcus pneumoniae is the major cause of otitis media in this population. Infants are protected against bacterial disease in the first months of life by passive transfer of maternal antibody across the placenta during the late stages of gestation. We hypothesized that reduced passive immunity may contribute to increased disease risk in this population. We compared the concentrations and function of serotype-specific IgG in cord serum from Australian indigenous neonates and Gambian neonates, the latter experiences a similar socioeconomic status to Australian indigenous neonates.

Methods: Serotype-specific IgG, IgG1 and IgG2 were measured using a modified 3rd generation enzyme linked immunosorbent assay based on World Health Organization recommendations. Antibody avidity was measured using a modified sodium thiocyanate elution method.

Results: Australian indigenous neonates had significantly increased levels of serotype-specific IgG compared with Gambian populations for 6 of 12 serotypes (P < 0.02). There was no significant difference in antibody function, as measured by antibody avidity, between the 2 groups.

Conclusions: An increased risk for otitis media in Australian indigenous neonates is not primarily determined by specific antibody titers against pneumococcal bacteria. Further investigation into the possible roles of the innate immune response and Eustachian tube dysfunction in the development of chronic otitis media amongst Australian indigenous infants is warranted.
Keywords pneumococcal antibodies
cord blood
otitis media
passive transfer
DOI http://dx.doi.org/10.1097/INF.0000000000000202   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
Versions
Version Filter Type
Access Statistics: 83 Abstract Views  -  Detailed Statistics
Created: Wed, 19 Aug 2015, 12:14:08 CST