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Genetic and epigenetic variation in vulvar cancer: Current research and future clinical practice

McWhirter, Rebekah, Marthick, James R., Boyle, Jacqueline A. and Dickinson, Joanne L. (2014). Genetic and epigenetic variation in vulvar cancer: Current research and future clinical practice. Australian and New Zealand Journal of Obstetrics and Gynaecology,54:406-411.

Document type: Journal Article
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IRMA ID 75039815xPUB290
Title Genetic and epigenetic variation in vulvar cancer: Current research and future clinical practice
Author McWhirter, Rebekah
Marthick, James R.
Boyle, Jacqueline A.
Dickinson, Joanne L.
Journal Name Australian and New Zealand Journal of Obstetrics and Gynaecology
Publication Date 2014
Volume Number 54
ISSN 1479-828X   (check CDU catalogue  open catalogue search in new window)
Scopus ID 2-s2.0-84907813835
Start Page 406
End Page 411
Total Pages 6
Place of Publication Australia
Publisher Wiley-Blackwell Publishing Asia
HERDC Category C1 - Journal Article (DIISR)
Abstract Vulvar cancer is a relatively rare gynaecological malignancy, the treatment of which is associated with significant patient morbidity. With reports that the incidence of vulvar cancer is increasing, there is a rising need for improved preventive, diagnostic and therapeutic tools. Recent advances within genetics and epigenetics present possible approaches for addressing this need, by contributing to the clarification of the aetiology of this disease, identifying screening and drug targets and introducing the potential for personalised treatments. This paper reviews the genetic and epigenetic research undertaken to date within vulvar cancer, evaluates its potential for clinical application and identifies directions for future research.
Keywords Epigenetics
Genetics
Human papillomavirus
Vulvar cancer
Vulvar intraepithelial neoplasia
DOI http://dx.doi.org/10.1111/ajo.12241   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
Description for Link Link to publisher's version
URL http://onlinelibrary.wiley.com/doi/10.1111/ajo.12241/abstract;jsessionid=57B04BDFF03D2269FCBBFF625EEC682B.f03t04
 
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