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Impaired serotype-specific immune function following pneumococcal vaccination in infants with prior carriage

Licciardi, Paul V., Russell, Fiona, Balloch, Anne, Burton, Robert, Nahm, Moon, Gilbert, Gwendolyn, Tang, Mimi and Mulholland, E. Kim (2014). Impaired serotype-specific immune function following pneumococcal vaccination in infants with prior carriage. Vaccine,32(20):2321-2327.

Document type: Journal Article
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IRMA ID 75039815xPUB295
Title Impaired serotype-specific immune function following pneumococcal vaccination in infants with prior carriage
Author Licciardi, Paul V.
Russell, Fiona
Balloch, Anne
Burton, Robert
Nahm, Moon
Gilbert, Gwendolyn
Tang, Mimi
Mulholland, E. Kim
Journal Name Vaccine
Publication Date 2014
Volume Number 32
Issue Number 20
ISSN 0264-410X   (check CDU catalogue open catalogue search in new window)
Scopus ID 2-s2.0-84897539023
Start Page 2321
End Page 2327
Total Pages 7
Place of Publication United Kingdom
Publisher Elsevier Ltd
HERDC Category C1 - Journal Article (DIISR)
Abstract The impact of prior nasopharyngeal carriage on serotype-specific IgG responses following immunization with pneumococcal conjugate vaccines (PCV) has recently been described. This report extends these findings to describe the attenuation of functional immune responses following 23-valent pneumococcal polysaccharide vaccination (PPS). We report the attenuation of immune responses following booster with the 23-valent pneumococcal polysaccharide vaccination (PPS) in infants with prior nasopharyngeal carriage of Streptococcus pneumoniae. Fijian infants who were part of a phase II randomized, controlled trial of reduced dose PCV7 schedules were the basis of this study. Pneumococcal carriage was determined at 6, 9 and 12 months of age, prior to PPS immunization. Serum samples collected at 18 weeks (post-PCV7), 12 months (pre-PPS), 12.5 months and 17 months (post-PPS) of age were assessed for serotype-specific IgG and opsonophagocytic responses.

The most frequently carried serotypes were 6B (N = 11), 19F (N = 14) and 23F (N = 23). Significantly lower serotype-specific IgG for 19F, 23F but not 6B post-PPS were detected in infants with homologous serotype carriage prior to PPS compared with non-carriers (N = 230). However, OPA levels for 6B and 23F were lower in infants that carried these serotypes.

Pneumococcal carriage with 19F or 23F at any time prior to PPS immunization in infants at 12 months of age who were previously primed with PCV resulted in serotype-specific hyporesponsiveness that persisted until 17 months of age. These results may have implications for the timing of infant vaccine schedules, particularly in high disease burden settings.
Keywords Pneumococcal
Carriage
PPS
Opsonophagocytosis
Hyporesponsiveness
DOI http://dx.doi.org/10.1016/j.vaccine.2014.02.064   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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