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Intraindividual variation in urinary iodine concentrations: effect of adjustment on population distribution using two and three repeated spot urine collections

Charlton, Karen E., Batterham, Marijka J., Buchanan, Li Min and Mackerras, Dorothy (2014). Intraindividual variation in urinary iodine concentrations: effect of adjustment on population distribution using two and three repeated spot urine collections. BMJ Open,4(1 - Article No. e003799).

Document type: Journal Article
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IRMA ID 75039815xPUB300
Title Intraindividual variation in urinary iodine concentrations: effect of adjustment on population distribution using two and three repeated spot urine collections
Author Charlton, Karen E.
Batterham, Marijka J.
Buchanan, Li Min
Mackerras, Dorothy
Journal Name BMJ Open
Publication Date 2014
Volume Number 4
Issue Number 1 - Article No. e003799
ISSN 2044-6055   (check CDU catalogue  open catalogue search in new window)
Scopus ID 2-s2.0-84892884627
Total Pages 6
Place of Publication United Kingdom
Publisher B M J Group
HERDC Category C1 - Journal Article (DIISR)
Abstract Objectives To determine the effect of adjustment for intraindividual variation on estimations of urinary iodine concentrations (UIC), prevalence of iodine deficiency and population distribution of iodine status.

Setting
Community-dwelling older adults from New South Wales, Australia.

Participants
84 healthy men and women aged 60–95 years were recruited prior to introduction of the mandatory iodine fortification programme.

Primary and secondary outcome measures
UIC data were collected from three spot urine samples, each 1 week apart. Repeated measures analysis of variance were determined between-person (sb) and total (sobs) SDs. Adjusted UIC values were calculated as ((person's UIC−group mean)×(sb/sobs))+group mean, and a corrected UIC distribution was calculated.

Results
The sb/sobs for using three samples and two samples were 0.83 and 0.79, respectively. Following adjustment for intraindividual variation, the proportion with UIC <50 μg/L reduced from 33% to 19%, while the proportion with UIC ≥100 μg/L changed from 21% to 17%. The 95th centile for UIC decreased from 176 to 136 μg/L. Adjustment by taking averages yielded a lesser degree of contraction in the distribution than the analysis of variance method.

Conclusions
The addition of information about intraindividual variability has potential for increasing the interpretability of UIC data collected to monitor the iodine status of a population.
DOI http://dx.doi.org/10.1136/bmjopen-2013-003799   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
Additional Notes This is an Open Access article distributed under the terms of the Creative Commons Attribution License 3.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Description for Link Link to CC Attribution 3.0 License
URL https://creativecommons.org/licenses/by/3.0/au


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