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Methods to assess the impact of mass oral cholera vaccination campaigns under real field conditions

Deen, Jacqueline L., Ali, Mohammad and Sack, David (2014). Methods to assess the impact of mass oral cholera vaccination campaigns under real field conditions. PLoS One,9(2 - Article No. e88139).

Document type: Journal Article
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IRMA ID 75039815xPUB307
Title Methods to assess the impact of mass oral cholera vaccination campaigns under real field conditions
Author Deen, Jacqueline L.
Ali, Mohammad
Sack, David
Journal Name PLoS One
Publication Date 2014
Volume Number 9
Issue Number 2 - Article No. e88139
ISSN 1932-6203   (check CDU catalogue  open catalogue search in new window)
Scopus ID 2-s2.0-84895735003
Total Pages 7
Place of Publication United States of America
Publisher Public Library of Science
HERDC Category C1 - Journal Article (DIISR)
Abstract There is increasing interest to use oral cholera vaccination as an additional strategy to water and sanitation interventions against endemic and epidemic cholera. There are two internationally-available and WHO-prequalified oral cholera vaccines: an inactivated vaccine containing killed whole-cells of V. cholerae O1 with recombinant cholera toxin B-subunit (WC/rBS) and a bivalent inactivated vaccine containing killed whole cells of V. cholerae O1 and V. cholerae O139 (BivWC). The efficacy, effectiveness, direct and indirect (herd) protection conferred by WC/rBS and BivWC are well established. Yet governments may need local evidence of vaccine impact to justify and scale-up mass oral cholera vaccination campaigns. We discuss various approaches to assess oral cholera vaccine protection, which may be useful to policymakers and public health workers considering deployment and evaluation of the vaccine.
DOI http://dx.doi.org/10.1371/journal.pone.0088139   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)


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