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Vaccines for children and adults with chronic lung disease: efficacy against acute exacerbations

O'Grady, Kerry-Ann F., Chang, Anne B. and Grimwood, Keith (2014). Vaccines for children and adults with chronic lung disease: efficacy against acute exacerbations. Expert Review of Respiratory Medicine,8(1):43-55.

Document type: Journal Article
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IRMA ID 75039815xPUB347
Title Vaccines for children and adults with chronic lung disease: efficacy against acute exacerbations
Author O'Grady, Kerry-Ann F.
Chang, Anne B.
Grimwood, Keith
Journal Name Expert Review of Respiratory Medicine
Publication Date 2014
Volume Number 8
Issue Number 1
ISSN 1747-6348   (check CDU catalogue open catalogue search in new window)
Scopus ID 2-s2.0-84893064643
Start Page 43
End Page 55
Total Pages 13
Place of Publication United Kingdom
Publisher Taylor & Francis
HERDC Category C1 - Journal Article (DIISR)
Abstract Acute exacerbations of chronic lung disease are usually associated with viral and bacterial pathogens. They contribute to declining lung function, poor quality of life and exert an excess burden on individuals, families, communities and the healthcare sector. Hence, preventing exacerbations is important in clinical management. Several vaccines providing protection against respiratory pathogens (Streptococcus pneumoniae, Bordetella pertussis and influenza) that can trigger exacerbations are available, but evidence to support their effectiveness in preventing exacerbations of chronic lung disease is limited. Candidate vaccines in pre-clinical or clinical development phases include those targeting Haemophilus influenzae, Moraxella catarrhalis, Staphylococcus aureus, Pseudomonas aeruginosa, respiratory syncytial virus and human rhinoviruses. However, it is likely to be several years before vaccines against these pathogens are available for children and adults with chronic lung diseases. For vaccination to play an important role in managing chronic lung disease efforts need to be directed at understanding how various pathogens cause exacerbations and alter long-term lung function.
Keywords acute respiratory exacerbations
chronic lung disease
prevention
vaccine efficacy
vaccines
DOI http://dx.doi.org/10.1586/17476348.2014.852960   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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