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Oral cholera vaccine development and use in Vietnam

Anh, Dang Duc, Lopez, Anna Lena, Tran, Hung Thi Mai, Cuong, Nguyen Van, Thiem, Vu Dinh, Ali, Mohammad, Deen, Jacqueline L., von Seidlein, Lorenz and Sack, David A. (2014). Oral cholera vaccine development and use in Vietnam. PLoS Medicine,11(9 - Article No. e1001712).

Document type: Journal Article
Citation counts: Altmetric Score Altmetric Score is 31
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IRMA ID 75039815xPUB550
Title Oral cholera vaccine development and use in Vietnam
Author Anh, Dang Duc
Lopez, Anna Lena
Tran, Hung Thi Mai
Cuong, Nguyen Van
Thiem, Vu Dinh
Ali, Mohammad
Deen, Jacqueline L.
von Seidlein, Lorenz
Sack, David A.
Journal Name PLoS Medicine
Publication Date 2014
Volume Number 11
Issue Number 9 - Article No. e1001712
ISSN 1549-1277   (check CDU catalogue open catalogue search in new window)
Scopus ID 2-s2.0-84907960265
Total Pages 7
Place of Publication United States of America
Publisher Public Library of Science
HERDC Category C1 - Journal Article (DIISR)
Abstract Vietnam is the first and only country in the world to regularly use oral cholera vaccines (OCVs) in their cholera control program.

From 1998 to 2012, more than 10.9 million doses of the locally produced OCV were deployed in the country through its public health system.

 We present an overview of cholera epidemiology in Vietnam and the development and deployment of the OCV.

Since 1997, the number of cholera cases in Vietnam has declined, in association with increased OCV use as well as improvements in socioeconomic and water and sanitation conditions. It is not possible to establish the relative contributions of each of these to the reduction in cholera rates.

Hue, the only province to use OCVs consistently every year, has not reported any cholera case since 2003.

As WHO organizes a stockpile of OCV for use in emergencies and recommends the use of OCVs together with traditional means of control, the experience in Vietnam will be helpful to other at-risk countries as they look towards adopting the vaccine in their cholera control programs.
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