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Crusted scabies is associated with increased IL-17 secretion by skin T cells

Liu, Xiaosong, Walton, Shelley F., Murray, Hugh C., King, Mallory, Holt, Deborah C., Currie, Bart J., McCarthy, James, Mounsey, Kate and Kelly, A. (2014). Crusted scabies is associated with increased IL-17 secretion by skin T cells. Parasite Immunology,36(11):592-602.

Document type: Journal Article
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IRMA ID 75039815xPUB674
Title Crusted scabies is associated with increased IL-17 secretion by skin T cells
Author Liu, Xiaosong
Walton, Shelley F.
Murray, Hugh C.
King, Mallory
Holt, Deborah C.
Currie, Bart J.
McCarthy, James
Mounsey, Kate
Kelly, A.
Journal Name Parasite Immunology
Publication Date 2014
Volume Number 36
Issue Number 11
ISSN 0141-9838   (check CDU catalogue open catalogue search in new window)
Start Page 592
End Page 602
Total Pages 11
Place of Publication United Kingdom
Publisher Wiley-Blackwell Publishing Ltd.
HERDC Category C1 - Journal Article (DIISR)
Abstract Scabies is an ectoparasitic infestation by the mite Sarcoptes scabiei. Although commonly self-limiting, a fraction of patients develop severely debilitating crusted scabies. The immune mechanisms underlying the development of crusted scabies are unclear, and undertaking longitudinal infection studies in humans is difficult. We utilized a porcine model to compare cellular immune responses in peripheral blood and skin of pigs with different clinical manifestations of scabies (n = 12), and in uninfected controls (n = 6). Although clinical symptoms were not evident until at least 4 weeks post-infestation, the numbers of peripheral IFNγ-secreting CD4+ T cells and γδ T cells increased in infected pigs from week 1 post-infestation. γδ T cells remained increased in the blood at week 15 post-infestation. At week 15, skin cell infiltrates from pigs with crusted scabies had significantly higher CD8+ T cell, γδ T cell and IL-17+ cell numbers than those with ordinary scabies. Peripheral IL-17 levels were not increased, suggesting that localized skin IL-17-secreting T cells may play a critical role in the pathogenesis of crusted scabies development. Given the potential of anti-IL-17 immunotherapy demonstrated for other inflammatory skin diseases, this study may provide a novel therapeutic avenue for patients with recurrent crusted scabies.
Keywords crusted scabies
γδ T cells
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