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Geographic variation in the eukaryotic virome of human diarrhea

Holtz, Lori, Cao, Song, Zhao, Guoyan, Bauer, Irma, Denno, Donna, Klein, Eileen, Antonio, Martin, Stine, O., Snelling, Thomas, Kirkwood, Carl and Wang, David (2014). Geographic variation in the eukaryotic virome of human diarrhea. Virology,468-470:556-564.

Document type: Journal Article
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IRMA ID 75039815xPUB701
Title Geographic variation in the eukaryotic virome of human diarrhea
Author Holtz, Lori
Cao, Song
Zhao, Guoyan
Bauer, Irma
Denno, Donna
Klein, Eileen
Antonio, Martin
Stine, O.
Snelling, Thomas
Kirkwood, Carl
Wang, David
Journal Name Virology
Publication Date 2014
Volume Number 468-470
ISSN 1096-0341   (check CDU catalogue  open catalogue search in new window)
Start Page 556
End Page 564
Total Pages 9
Place of Publication United States
Publisher Academic Press
HERDC Category C1 - Journal Article (DIISR)
Abstract Little is known about the population of eukaryotic viruses in the human gut (“virome”) or the potential role it may play in disease. We used a metagenomic approach to define and compare the eukaryotic viromes in pediatric diarrhea cohorts from two locations (Melbourne and Northern Territory, Australia). We detected viruses known to cause diarrhea, non-pathogenic enteric viruses, viruses not associated with an enteric reservoir, viruses of plants, and novel viruses. Viromes from Northern Territory children contained more viral families per sample than viromes from Melbourne, which could be attributed largely to an increased number of sequences from the families Adenoviridae and Picornaviridae (genus enterovirus). qRT-PCR/PCR confirmed the increased prevalence of adenoviruses and enteroviruses. Testing of additional diarrhea cohorts by qRT-PCR/PCR demonstrated statistically different prevalences in different geographic sites. These findings raise the question of whether the virome plays a role in enteric diseases and conditions that vary with geography.
Keywords Diarrhea
Virome
Metagenomics
DOI http://dx.doi.org/10.1016/j.virol.2014.09.012   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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