Charles Darwin University

CDU eSpace
Institutional Repository

 
CDU Staff and Student only
 

Differential targeting and shifts in the immunodominance of Epstein-Barr virus-specific CD8 and CD4 T cell responses during acute and persistent infection

Woodberry, Tonia, Suscovich, T., Henry, L., Davis, Jane, Frahm, N., Walker, B., Scadden, D., Wang, F. and Brander, C. (2005). Differential targeting and shifts in the immunodominance of Epstein-Barr virus-specific CD8 and CD4 T cell responses during acute and persistent infection. Journal of Infectious Diseases,192(9):1513-1524.

Document type: Journal Article
Citation counts:
Google Scholar Search Google Scholar

IRMA ID 10291xPUB12
Title Differential targeting and shifts in the immunodominance of Epstein-Barr virus-specific CD8 and CD4 T cell responses during acute and persistent infection
Author Woodberry, Tonia
Suscovich, T.
Henry, L.
Davis, Jane
Frahm, N.
Walker, B.
Scadden, D.
Wang, F.
Brander, C.
Journal Name Journal of Infectious Diseases
Publication Date 2005
Volume Number 192
Issue Number 9
ISSN 1537-6613   (check CDU catalogue open catalogue search in new window)
Start Page 1513
End Page 1524
Total Pages 12
Place of Publication US
Publisher Infectious Diseases Society of America
Field of Research 1103 - Clinical Sciences
1108 - Medical Microbiology
HERDC Category C1 - Journal Article (DEST)
Abstract The evolution of Epstein-Barr virus (EBV)-specific T cell responses that occurs during the acute and persistent stages of infection remains poorly characterized despite its importance for developing immune interventions for EBV-associated disorders. This study assessed T cell responses to 113 EBV-derived epitopes in 40 subjects with acute or persistent EBV infection. Although no significant differences were seen in the breadth of CD8 and CD4 T cell responses, their magnitude differed significantly over time; acutely infected subjects generated especially strong responses to lytic viral antigens. The cross-sectional shift in immunodominance was also confirmed in subjects followed longitudinally from acute to persistent infection. In addition, human leukocyte antigen-matched siblings with discordant histories of symptomatic EBV infection showed no significant differences in their response patterns, suggesting that symptomatic EBV infection does not lead to unique persistent-stage responses. These data provide an assessment of immunodominance patterns and guidance for developing immunotherapeutic interventions for EBV-associated disorders.
Keywords cell
Epstein-Barr virus
immunodominance
infection
DOI http://dx.doi.org/10.1086/491741   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
Additional Notes 3617 (Journal) DA - 20051005IS - 0022-1899 (Print)LA - engPT - Comparative StudyPT - Journal ArticlePT - Research Support, N.I.H., ExtramuralRN - 0 (Epitopes, T-Lymphocyte)RN - 0 (Histocompatibility Antigens Class I)RN - 0 (Histocompatibility Antigens Class II)RN - 0 (Immunodominant Epitopes)SB - AIMSB - IM
 
Versions
Version Filter Type
Access Statistics: 108 Abstract Views  -  Detailed Statistics
Created: Mon, 17 Dec 2007, 09:02:11 CST