Charles Darwin University

CDU eSpace
Institutional Repository

 
CDU Staff and Student only
 

Relationship between urinary sodium excretion and serum aldosterone in patients with diabetes in the presence and absence of modifiers of the renin-angiotensin-aldosterone system

Libianto, Renata, Jerums, George, Lam, Que, Chen, Angela, Baqar, Sara, Pyrlis, Felicity, MacIsaac, Richard, Moran, John and Ekinci, Elif (2014). Relationship between urinary sodium excretion and serum aldosterone in patients with diabetes in the presence and absence of modifiers of the renin-angiotensin-aldosterone system. Clinical Science,126(2):147-154.

Document type: Journal Article
Citation counts: Altmetric Score Altmetric Score is 3
Google Scholar Search Google Scholar

IRMA ID cmartelxPUB111
Title Relationship between urinary sodium excretion and serum aldosterone in patients with diabetes in the presence and absence of modifiers of the renin-angiotensin-aldosterone system
Author Libianto, Renata
Jerums, George
Lam, Que
Chen, Angela
Baqar, Sara
Pyrlis, Felicity
MacIsaac, Richard
Moran, John
Ekinci, Elif
Journal Name Clinical Science
Publication Date 2014
Volume Number 126
Issue Number 2
ISSN 0143-5221   (check CDU catalogue open catalogue search in new window)
Scopus ID 2-s2.0-84885081716
Start Page 147
End Page 154
Total Pages 8
Place of Publication United Kingdom
Publisher Portland Press Ltd.
HERDC Category C1 - Journal Article (DIISR)
Abstract Although low dietary salt intake has beneficial effects on BP (blood pressure), low 24hUNa (24 h urinary sodium excretion), the most accurate estimate of dietary salt intake, is associated with increased mortality in people with diabetes. In the non-diabetic population, low salt intake is associated with increased RAAS (renin–angiotensin–aldosterone system) activity. In this cross-sectional study, we examined the relationship between 24hUNa, PRA (plasma renin activity), serum aldosterone and BNP (brain natriuretic peptide) in patients with diabetes. Clinical characteristics, 24hUNa, PRA, serum aldosterone and BNP were recorded in 222 consecutive patients (77% with Type 2 diabetes) attending a diabetes clinic at a tertiary hospital. The relationship between 24hUNa, serum aldosterone, PRA, BNP, urinary potassium excretion, serum potassium, serum sodium, eGFR (estimated glomerular filtration rate), urinary albumin excretion and HbA1c (glycated haemoglobin) was examined by a multivariable regression model. Levels of 24hUNa significantly predicted serum aldosterone in a linear fashion (R2=0.20, P=0.002). In the subgroup of patients (n=46) not taking RAAS-modifying agents, this relationship was also observed (R2=0.10, P=0.03), and the effect of 24hUNa on serum aldosterone was found to be more pronounced than in the whole cohort (coefficient=−0.0014, compared with −0.0008). There was no demonstrable relationship between 24hUNa and PRA or BNP. Low 24hUNa is associated with increased serum aldosterone in people with diabetes, in the presence and absence of RAAS-modifying agents. This raises the possibility that stimulation of the RAAS may be a mechanism that contributes to adverse outcomes observed in patients with low 24hUNa
DOI http://dx.doi.org/10.1042/CS20130128   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
Versions
Version Filter Type
Access Statistics: 21 Abstract Views  -  Detailed Statistics
Created: Wed, 19 Aug 2015, 12:33:56 CST