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Decreased Endothelial Nitric Oxide Bioavailability, Impaired Microvascular Function, and Increased Tissue Oxygen Consumption in Children with Falciparum Malaria

Yeo, Tsin W., Lampah, Daniel A., Kenangalem, Enny, Tjitra, Emiliana, Weinberg, J. Brice, Granger, Donald L., Price, Ric N. and Anstey, Nicholas M. (2014). Decreased Endothelial Nitric Oxide Bioavailability, Impaired Microvascular Function, and Increased Tissue Oxygen Consumption in Children with Falciparum Malaria. Journal of Infectious Diseases,210(10):1627-1632.

Document type: Journal Article
Citation counts: Altmetric Score Altmetric Score is 4
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IRMA ID cmartelxPUB182
Title Decreased Endothelial Nitric Oxide Bioavailability, Impaired Microvascular Function, and Increased Tissue Oxygen Consumption in Children with Falciparum Malaria
Author Yeo, Tsin W.
Lampah, Daniel A.
Kenangalem, Enny
Tjitra, Emiliana
Weinberg, J. Brice
Granger, Donald L.
Price, Ric N.
Anstey, Nicholas M.
Journal Name Journal of Infectious Diseases
Publication Date 2014
Volume Number 210
Issue Number 10
ISSN 0022-1899   (check CDU catalogue open catalogue search in new window)
Scopus ID 2-s2.0-84912125425
Start Page 1627
End Page 1632
Total Pages 6
Place of Publication United States of America
Publisher Oxford University Press
HERDC Category C1 - Journal Article (DIISR)
Abstract Endothelial nitric oxide (NO) bioavailability, microvascular function, and host oxygen consumption have not been assessed in pediatric malaria. We measured NO-dependent endothelial function by using peripheral artery tonometry to determine the reactive hyperemia index (RHI), and microvascular function and oxygen consumption (VO2) using near infrared resonance spectroscopy in 13 Indonesian children with severe falciparum malaria and 15 with moderately severe falciparum malaria. Compared with 19 controls, children with severe malaria and those with moderately severe malaria had lower RHIs (P = .03); 12% and 8% lower microvascular function, respectively (P = .03); and 29% and 25% higher VO2, respectively. RHIs correlated with microvascular function in all children with malaria (P < .001) and all with severe malaria (P < .001). Children with malaria have decreased endothelial and microvascular function and increased oxygen consumption, likely contributing to the pathogenesis of the disease.
Keywords Severe malaria
Cerebral malaria
Plasmodium falciparum
Endothelial function
Microvascular function
Oxygen consumption
Tissue hypoxia
DOI http://dx.doi.org/10.1093/infdis/jiu308   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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