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Genetic diversity and population structure of Plasmodium vivax in Central China

Liu, Yaobao, Auburn, Sarah, Cao, Jun, Trimarsanto, Hidayat, Zhou, Huayun, Gray, Karen-Ann, Clark, Taane, Price, Ric, Cheng, Qin, Huang, Rui and Gao, Qi (2014). Genetic diversity and population structure of Plasmodium vivax in Central China. Malaria Journal,13(1 - Article No. 262).

Document type: Journal Article
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IRMA ID cmartelxPUB189
Title Genetic diversity and population structure of Plasmodium vivax in Central China
Author Liu, Yaobao
Auburn, Sarah
Cao, Jun
Trimarsanto, Hidayat
Zhou, Huayun
Gray, Karen-Ann
Clark, Taane
Price, Ric
Cheng, Qin
Huang, Rui
Gao, Qi
Journal Name Malaria Journal
Publication Date 2014
Volume Number 13
Issue Number 1 - Article No. 262
ISSN 1475-2875   (check CDU catalogue open catalogue search in new window)
Scopus ID 2-s2.0-84903871349
Total Pages 12
Place of Publication United Kingdom
Publisher BioMed Central Ltd.
HERDC Category C1 - Journal Article (DIISR)
Abstract Background: In Central China the declining incidence of Plasmodium vivax has been interrupted by epidemic expansions and imported cases. The impact of these changes on the local parasite population, and concurrent risks of future resurgence, was assessed.

Methods: Plasmodium vivax isolates collected from Anhui and Jiangsu provinces, Central China between 2007 and 2010 were genotyped using capillary electrophoresis at seven polymorphic short tandem repeat markers. Spatial and temporal analyses of within-host and population diversity, population structure, and relatedness were conducted on these isolates.

Results: Polyclonal infections were infrequent in the 94 isolates from Anhui (4%) and 25 from Jiangsu (12%), with a trend for increasing frequency from 2008 to 2010 (2 to 19%) when combined. Population diversity was high in both provinces and across the years tested (HE = 0.8 – 0.85). Differentiation between Anhui and Jiangsu was modest (F’ST = 0.1). Several clusters of isolates with identical multi-locus haplotypes were observed across both Anhui and Jiangsu. Linkage disequilibrium was strong in both populations and in each year tested (IA S = 0.2 – 0.4), but declined two- to four-fold when identical haplotypes were accounted for, indicative of occasional epidemic transmission dynamics. None of five imported isolates shared identical haplotypes to any of the central Chinese isolates.

Conclusions: The population genetic structure of P. vivax in Central China highlights unstable transmission, with limited barriers to gene flow between the central provinces. Despite low endemicity, population diversity remained high, but the reservoirs sustaining this diversity remain unclear. The challenge of imported cases and risks of resurgence emphasize the need for continued surveillance to detect early warning signals. Although parasite genotyping has potential to inform the management of outbreaks, further studies are required to identify suitable marker panels for resolving local from imported P. vivax isolates.
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