Charles Darwin University

CDU eSpace
Institutional Repository

 
CDU Staff and Student only
 

Application of pharmacokinetic-pharmacodynamic modeling in management of QT abnormalities after citalopram overdose. Reply to A. Manini

Isbister, Geoffrey K., Friberg, Lena E. and Duffull, Stephen B. (2007). Application of pharmacokinetic-pharmacodynamic modeling in management of QT abnormalities after citalopram overdose. Reply to A. Manini. Intensive Care Medicine,33(4):739-739.

Document type: Journal Article
Citation counts:
Google Scholar Search Google Scholar

Title Application of pharmacokinetic-pharmacodynamic modeling in management of QT abnormalities after citalopram overdose. Reply to A. Manini
Author Isbister, Geoffrey K.
Friberg, Lena E.
Duffull, Stephen B.
Journal Name Intensive Care Medicine
Publication Date 2007
Volume Number 33
Issue Number 4
ISSN 0342-4642   (check CDU catalogue open catalogue search in new window)
Start Page 739
End Page 739
Place of Publication Heidelberg
Publisher Springer
HERDC Category C4 - Journal Article - Letter or Note (internal)
Abstract Sir, Manini et al. express concerns about the algorithm that we developed for the management of cardiotoxicity in citalopram overdose. We respond to their comments as follows:

In the algorithm we use “dose estimate” and not “ingested dose”. The difference between the dose amount reported (based on the patient history, tablet counts and other available information) and the dose amount estimated in the modelling ranged from 0 to 75 mg, i.e. the reported dose amount was acceptably reliable [1].

Of the three published cases that the authors quote where patients ingested less than 600 mg [2, 3, 4], two did not have an abnormal QT based on the QT nomogram derived from Fossa et al. [5, 6]. Bazett's correction was used in these two cases despite its known overcorrection in patients with fast heart rates. In the third case, a patient was reported to have sinus tachycardia, but absolute QT and RR was not reported, in addition to an uncertainty in the reported dose [2].
Keywords citalopram
overdose
pharmacokinetic
DOI http://dx.doi.org/10.1007/s00134-006-0506-x   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
Versions
Version Filter Type
Access Statistics: 48 Abstract Views  -  Detailed Statistics
Created: Mon, 08 Sep 2008, 16:16:22 CST