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Comparative Accuracy of the InBios Scrub Typhus Detect IgM Rapid Test for the Detection of IgM Antibodies by Using Conventional Serology

Kingston, Hugh W. F., Blacksell, Stuart D., Tanganuchitcharnchai, Ampai, Laongnualpanich, Achara, Basnyat, Buddha, Day, Nicholas P. J. and Paris, Daniel H. (2015). Comparative Accuracy of the InBios Scrub Typhus Detect IgM Rapid Test for the Detection of IgM Antibodies by Using Conventional Serology. Clinical and Vaccine Immunology,22(10):1130-1132.

Document type: Journal Article
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IRMA ID 81144320xPUB100
Title Comparative Accuracy of the InBios Scrub Typhus Detect IgM Rapid Test for the Detection of IgM Antibodies by Using Conventional Serology
Author Kingston, Hugh W. F.
Blacksell, Stuart D.
Tanganuchitcharnchai, Ampai
Laongnualpanich, Achara
Basnyat, Buddha
Day, Nicholas P. J.
Paris, Daniel H.
Journal Name Clinical and Vaccine Immunology
Publication Date 2015
Volume Number 22
Issue Number 10
ISSN 1556-6811   (check CDU catalogue  open catalogue search in new window)
Scopus ID 2-s2.0-84943262734
Start Page 1130
End Page 1132
Total Pages 3
Place of Publication United States of America
Publisher American Society for Microbiology
HERDC Category C1 - Journal Article (DIISR)
Abstract This study investigated the comparative accuracy of a recombinant 56-kDa type-specific antigen-based rapid diagnostic test (RDT) for scrub typhus for the detection of IgM antibodies by using conventional serology in well-characterized serum samples from undifferentiated febrile illness patients. The RDT showed high specificity and promising comparative accuracy, with 82% sensitivity and 98% specificity for samples defined positive at an IgM indirect immunofluorescence assay positivity cutoff titer of ≥1:1,600 versus 92% and 95% at ≥1:6,400, respectively.
DOI http://dx.doi.org/10.1128/CVI.00390-15   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
Additional Notes This is an Open Access article distributed under the terms of the Creative Commons Attribution License 3.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Description for Link Link to CC Attribution 3.0 License
URL https://creativecommons.org/licenses/by/3.0/au


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