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Fucoidan and cancer: A multifunctional molecule with anti-tumor potential

Atashrazm, Farzaneh, Lowenthal, Ray M., Woods, Gregory M., Holloway, Adele F. and Dickinson, Joanne L. (2015). Fucoidan and cancer: A multifunctional molecule with anti-tumor potential. Marine Drugs,13(4):2327-2346.

Document type: Journal Article
Citation counts: Altmetric Score Altmetric Score is 28
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IRMA ID 83393865xPUB221
Title Fucoidan and cancer: A multifunctional molecule with anti-tumor potential
Author Atashrazm, Farzaneh
Lowenthal, Ray M.
Woods, Gregory M.
Holloway, Adele F.
Dickinson, Joanne L.
Journal Name Marine Drugs
Publication Date 2015
Volume Number 13
Issue Number 4
ISSN 1660-3397   (check CDU catalogue  open catalogue search in new window)
Scopus ID 2-s2.0-84928596437
Start Page 2327
End Page 2346
Total Pages 20
Place of Publication Switzerland
Publisher M D P I AG
HERDC Category C1 - Journal Article (DIISR)
Abstract There is a wide variety of cancer types yet, all share some common cellular and molecular behaviors. Most of the chemotherapeutic agents used in cancer treatment are designed to target common deregulated mechanisms within cancer cells. Many healthy tissues are also affected by the cytotoxic effects of these chemical agents. Fucoidan, a natural component of brown seaweed, has anti-cancer activity against various cancer types by targeting key apoptotic molecules. It also has beneficial effects as it can protect against toxicity associated with chemotherapeutic agents and radiation. Thus the synergistic effect of fucoidan with current anti-cancer agents is of considerable interest. This review discusses the mechanisms by which fucoidan retards tumor development, eradicates tumor cells and synergizes with anti-cancer chemotherapeutic agents. Challenges to the development of fucoidan as an anti-cancer agent will also be discussed.
Keywords Fucoidan
Cancer
Apoptosis
Synergy
DOI http://dx.doi.org/10.3390/md13042327   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
Additional Notes This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Description for Link Link to CC Attribution 4.0 License
URL https://creativecommons.org/licenses/by/4.0/au


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