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Genetic determinants of epigenetic patterns: Providing insight into disease

Cazaly, Emma, Charlesworth, Jac, Dickinson, Joanne L. and Holloway, Adele F. (2015). Genetic determinants of epigenetic patterns: Providing insight into disease. Molecular Medicine,21(26-Mar-15):400-409.

Document type: Journal Article
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IRMA ID 83393865xPUB222
Title Genetic determinants of epigenetic patterns: Providing insight into disease
Author Cazaly, Emma
Charlesworth, Jac
Dickinson, Joanne L.
Holloway, Adele F.
Journal Name Molecular Medicine
Publication Date 2015
Volume Number 21
Issue Number 26-Mar-15
ISSN 1076-1551   (check CDU catalogue open catalogue search in new window)
Scopus ID 2-s2.0-84940371194
Start Page 400
End Page 409
Total Pages 10
Place of Publication United States
Publisher The Feinstein Institute for Medical Research
HERDC Category C1 - Journal Article (DIISR)
Abstract The field of epigenetics and our understanding of the mechanisms that regulate the establishment, maintenance and heritability of epigenetic patterns continue to grow at a remarkable rate. This information is providing increased understanding of the role of epigenetic changes in disease, insight into the underlying causes of these epigenetic changes and revealing new avenues for therapeutic intervention. Epigenetic modifiers are increasingly being pursued as therapeutic targets in a range of diseases, with a number of agents targeting epigenetic modifications already proving effective in diseases such as cancer. Although it is well established that DNA mutations and aberrant expression of epigenetic modifiers play a key role in disease, attention is now turning to the interplay between genetic and epigenetic factors in complex disease etiology. The role of genetic variability in determining epigenetic profiles, which can then be modified by environmental and stochastic factors, is becoming more apparent. Understanding the interplay between genetic and epigenetic factors is likely to aid in identifying individuals most likely to benefit from epigenetic therapies. This goal is coming closer to realization because of continual advances in laboratory and statistical tools enabling improvements in the integration of genomic, epigenomic and phenotypic data
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Created: Tue, 26 Jul 2016, 12:40:26 CST