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A retrospective examination of mean relative telomere length in the Tasmanian Familial Hematological Malignancies Study

Blackburn, Nicholas B., Charlesworth, Jac C., Marthick, James R., Tegg, Elizabeth M., Marsden, Katherine A., Srikanth, Velandai, Blangero, John, Lowenthal, Ray M., Foote, Simon J. and Dickinson, Joanne L. (2015). A retrospective examination of mean relative telomere length in the Tasmanian Familial Hematological Malignancies Study. Oncology Reports,33(1):25-32.

Document type: Journal Article
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IRMA ID 83393865xPUB223
Title A retrospective examination of mean relative telomere length in the Tasmanian Familial Hematological Malignancies Study
Author Blackburn, Nicholas B.
Charlesworth, Jac C.
Marthick, James R.
Tegg, Elizabeth M.
Marsden, Katherine A.
Srikanth, Velandai
Blangero, John
Lowenthal, Ray M.
Foote, Simon J.
Dickinson, Joanne L.
Journal Name Oncology Reports
Publication Date 2015
Volume Number 33
Issue Number 1
ISSN 1021-335X   (check CDU catalogue open catalogue search in new window)
eISSN 1791-2431
Scopus ID 2-s2.0-84916225786
Start Page 25
End Page 32
Total Pages 8
Place of Publication Greece
Publisher Spandidos Publications
Field of Research MEDICAL AND HEALTH SCIENCES
HERDC Category C1 - Journal Article (DIISR)
Abstract Telomere length has a biological link to cancer, with excessive telomere shortening leading to genetic instability and resultant malignant transformation. Telomere length is heritable and genetic variants determining telomere length have been identified. Telomere biology has been implicated in the development of hematological malignancies (HMs), therefore, closer examination of telomere length in HMs may provide further insight into genetic etiology of disease development and support for telomere length as a prognostic factor in HMs. We retrospectively examined mean relative telomere length in the Tasmanian Familial Hematological Malignancies Study using a quantitative PCR method on genomic DNA from peripheral blood samples. Fifty-five familial HM cases, 191 unaffected relatives of familial HM cases and 75 non-familial HM cases were compared with 758 population controls. Variance components modeling was employed to identify factors influencing variation in telomere length. Overall, HM cases had shorter mean relative telomere length (p=2.9×10-6) and this was observed across both familial and non-familial HM cases (p=2.2x10-4 and 2.2x10-5, respectively) as well as additional subgroupings of HM cases according to broad subtypes. Mean relative telomere length was also significantly heritable (62.6%; p=4.7x10-5) in the HM families in the present study. We present new evidence of significantly shorter mean relative telomere length in both familial and non-familial HM cases from the same population adding further support to the potential use of telomere length as a prognostic factor in HMs. Whether telomere shortening is the cause of or the result of HMs is yet to be determined, but as telomere length was found to be highly heritable in our HM families this suggests that genetics driving the variation in telomere length is related to HM disease risk.
DOI http://dx.doi.org/10.3892/or.2014.3568   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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