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Reduced In Vitro Activity of Ceftaroline by Etest among Clonal Complex 239 Methicillin-Resistant Staphylococcus aureus Clinical Strains from Australia

Abbott, I. J., Jenney, A. W. J., Jeremiah, Cameron J., Mirčeta, M., Kandiah, J. P., Holt, Deborah C., Tong, Steven Y. C. and Spelman, Denis W. (2015). Reduced In Vitro Activity of Ceftaroline by Etest among Clonal Complex 239 Methicillin-Resistant Staphylococcus aureus Clinical Strains from Australia. Antimicrobial Agents and Chemotherapy,59(12):7837-7841.

Document type: Journal Article
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IRMA ID 11381xPUB178
NHMRC Grant No. 1065736
Title Reduced In Vitro Activity of Ceftaroline by Etest among Clonal Complex 239 Methicillin-Resistant Staphylococcus aureus Clinical Strains from Australia
Author Abbott, I. J.
Jenney, A. W. J.
Jeremiah, Cameron J.
Mirčeta, M.
Kandiah, J. P.
Holt, Deborah C.
Tong, Steven Y. C.
Spelman, Denis W.
Journal Name Antimicrobial Agents and Chemotherapy
Publication Date 2015
Volume Number 59
Issue Number 12
ISSN 0066-4804   (check CDU catalogue  open catalogue search in new window)
Scopus ID 2-s2.0-84954475513
Start Page 7837
End Page 7841
Total Pages 5
Place of Publication United States of America
Publisher American Society for Microbiology
HERDC Category C1 - Journal Article (DIISR)
Abstract A total of 421 methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates were tested for ceftaroline susceptibility by Etest (bioMérieux). A multidrug resistant phenotype was found in 40.9%, and clonal complex 239 (CC239) was found in 33.5%. Ceftaroline nonsusceptibility (MIC, >1.0 μg/ml) was 16.9% overall. Nonsusceptibility was significantly higher in CC239 (41.1%, 58/141) and in isolates with a multidrug resistant phenotype (35.5%, 61/172) compared with comparators (P < 0.0001). Nonsusceptibility of common multidrug resistant MRSA clones limits the empirical use of ceftaroline for these infections.
DOI http://dx.doi.org/10.1128/AAC.02015-15   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)


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