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Human papillomavirus prevalence to age 60 years among Australian women prevaccination

Brotherton, Julia M. L., Condon, John R., McIntyre, Peter B., Tabrizi, Sepehr N., Malloy, Michael, Garland, Suzanne M. and WHINURS Study Group (2015). Human papillomavirus prevalence to age 60 years among Australian women prevaccination. Sexual Health,12(4):353-359.

Document type: Journal Article
Citation counts: Altmetric Score Altmetric Score is 4
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IRMA ID 11381xPUB79
Title Human papillomavirus prevalence to age 60 years among Australian women prevaccination
Author Brotherton, Julia M. L.
Condon, John R.
McIntyre, Peter B.
Tabrizi, Sepehr N.
Malloy, Michael
Garland, Suzanne M.
WHINURS Study Group
Journal Name Sexual Health
Publication Date 2015
Volume Number 12
Issue Number 4
ISSN 1448-5028   (check CDU catalogue  open catalogue search in new window)
Scopus ID 2-s2.0-84938679047
Start Page 353
End Page 359
Total Pages 7
Place of Publication Australia
Publisher C S I R O Publishing
Field of Research MEDICAL AND HEALTH SCIENCES
HERDC Category C1 - Journal Article (DIISR)
Abstract Background: The prevalence of human papillomavirus (HPV) at the cervix varies with age, peaking following sexual debut and declining thereafter in most populations. In some populations, a second peak is observed. Here we describe the prevalence of HPV at the cervix among Australian women before the commencement of the HPV vaccination program.

Methods: Women aged 15 to 60 years attending health services for cervical screening between 2005 and 2008 were invited to participate. Liquid based cervical specimens were tested for 37 types of HPV using linear array. The percentage and 95% confidence interval of women with any type of HPV, any of 13 high risk HPV types, and with vaccine-preventable HPV types (types 6, 11, 16 and 18) were estimated in 5-year age bands.

Results: Among 1929 women aged 15–60 years, HPV prevalence peaked at 64% at age 15–20 years, then declined gradually to 12% at age 41–45 years, whereafter it rose to 19% in women 51–55 years then returned to 14% in 56–60 year olds. Prevalence curves were similar for high-risk HPV types and vaccine-targeted HPV types 6, 11, 16 and 18 and when results were restricted to women with only normal cytology.

Conclusions: The shape of the prevalence curve we observed is similar to those from other Western populations. Variation in prevalence curves is likely due to differences in sexual behaviour between populations and over time, reactivation of HPV during perimenopause, and possibly the presence of cervical screening programs. These data are the first such data from the Oceania region.
DOI http://dx.doi.org/10.1071/SH15035   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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