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Optimizing aerosolization of a high-dose L-arginine powder for pulmonary delivery

Lakio, Satu, Morton, David A.V., Ralph, Anna P. and Lambert, Pete (2015). Optimizing aerosolization of a high-dose L-arginine powder for pulmonary delivery. Asian Journal of Pharmaceutical Sciences,10(6):528-540.

Document type: Journal Article
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IRMA ID 11381xPUB163
Title Optimizing aerosolization of a high-dose L-arginine powder for pulmonary delivery
Author Lakio, Satu
Morton, David A.V.
Ralph, Anna P.
Lambert, Pete
Journal Name Asian Journal of Pharmaceutical Sciences
Publication Date 2015
Volume Number 10
Issue Number 6
ISSN 1818-0876   (check CDU catalogue  open catalogue search in new window)
Scopus ID 2-s2.0-84959542341
Start Page 528
End Page 540
Total Pages 13
Place of Publication Netherlands
Publisher Elsevier BV
HERDC Category C1 - Journal Article (DIISR)
Abstract In this study a carrier-free dry powder inhalation (DPI) containing L-arginine (ARG) was developed. As such, it is proposed that ARG could be used for adjunctive treatment of cystic fibrosis and/or tuberculosis. Various processing methods were used to manufacture high-dose formulation batches consisting various amounts of ARG and excipients. The formulations were evaluated using several analytical methods to assess suitability for further investigation. Several batches had enhanced in vitro aerolization properties. Significant future challenges include the highly hygroscopic nature of unformulated ARG powder and identifying the scale of dose of ARG required to achieve the response in lungs.
Keywords Pulmonary delivery
L-arginine
Spray drying
Mechanofusion
Dry powder inhalter (DPI)
Formulation
DOI http://dx.doi.org/10.1016/j.ajps.2015.08.001   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
Additional Notes This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Description for Link Link to CC Attribution 4.0 License
URL https://creativecommons.org/licenses/by/4.0/au


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