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The challenges of introducing routine G6PD testing into radical cure: a workshop report

Ley, Benedikt, Luter, Nick, Espino, Fe E., Devine, Angela, Kalnoky, Michael, Lubell, Yoel, Ley-Thriemer, Kamala, Baird, J. Kevin, Poirot, Eugenie, Conan, Nolwenn, Kheong, Chong Chee, Dysoley, Lek, Khan, Wasif Ali, Dion-Berboso, April G., Bancone, Germana, Hwang, Jimee, Kumar, Ritu, Price, Ric N., von Seidlein, Lorenz and Domingo, Gonzalo J. (2015). The challenges of introducing routine G6PD testing into radical cure: a workshop report. Malaria Journal,14(Article No. 377).

Document type: Journal Article
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IRMA ID 11381xPUB166
Title The challenges of introducing routine G6PD testing into radical cure: a workshop report
Author Ley, Benedikt
Luter, Nick
Espino, Fe E.
Devine, Angela
Kalnoky, Michael
Lubell, Yoel
Ley-Thriemer, Kamala
Baird, J. Kevin
Poirot, Eugenie
Conan, Nolwenn
Kheong, Chong Chee
Dysoley, Lek
Khan, Wasif Ali
Dion-Berboso, April G.
Bancone, Germana
Hwang, Jimee
Kumar, Ritu
Price, Ric N.
von Seidlein, Lorenz
Domingo, Gonzalo J.
Journal Name Malaria Journal
Publication Date 2015
Volume Number 14
Issue Number Article No. 377
ISSN 1475-2875   (check CDU catalogue open catalogue search in new window)
Scopus ID 2-s2.0-84942421382
Total Pages 12
Place of Publication United Kingdom
Publisher BioMed Central Ltd.
HERDC Category C1 - Journal Article (DIISR)
Abstract The only currently available drug that effectively removes malaria hypnozoites from the human host is primaquine. The use of 8-aminoquinolines is hampered by haemolytic side effects in glucose-6-phosphate dehydrogenase (G6PD) deficient individuals. Recently a number of qualitative and a quantitative rapid diagnostic test (RDT) format have been developed that provide an alternative to the current standard G6PD activity assays. The WHO has recently recommended routine testing of G6PD status prior to primaquine radical cure whenever possible. A workshop was held in the Philippines in early 2015 to discuss key challenges and knowledge gaps that hinder the introduction of routine G6PD testing. Two point-of-care (PoC) test formats for the measurement of G6PD activity are currently available: qualitative tests comparable to malaria RDT as well as biosensors that provide a quantitative reading. Qualitative G6PD PoC tests provide a binomial test result, are easy to use and some products are comparable in price to the widely used fluorescent spot test. Qualitative test results can accurately classify hemizygous males, heterozygous females, but may misclassify females with intermediate G6PD activity. Biosensors provide a more complex quantitative readout and are better suited to identify heterozygous females. While associated with higher costs per sample tested biosensors have the potential for broader use in other scenarios where knowledge of G6PD activity is relevant as well. The introduction of routine G6PD testing is associated with additional costs on top of routine treatment that will vary by setting and will need to be assessed prior to test introduction. Reliable G6PD PoC tests have the potential to play an essential role in future malaria elimination programmes, however require an improved understanding on how to best integrate routine G6PD testing into different health settings.
Keywords G6PD
Point of care test
Plasmodium vivax
Primaquine
Malaria
DOI http://dx.doi.org/10.1186/s12936-015-0896-8   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
Additional Notes This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Description for Link Link to CC Attribution 4.0 License
URL https://creativecommons.org/licenses/by/4.0/au


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