Charles Darwin University

CDU eSpace
Institutional Repository

 
CDU Staff and Student only
 

Reduced middle ear infection with non-typeable Haemophilus influenzae, but not Streptococcus pneumoniae, after transition to 10-valent pneumococcal non-typeable H. influenzae protein D conjugate vaccine

Leach, Amanda J., Wigger, Christine, Hare, Kim M., Hampton, Vanya R. S., Beissbarth, Jemima, Andrews, Ross M., Chatfield, Mark D., Smith-Vaughan, Heidi C. and Morris, Peter S. (2015). Reduced middle ear infection with non-typeable Haemophilus influenzae, but not Streptococcus pneumoniae, after transition to 10-valent pneumococcal non-typeable H. influenzae protein D conjugate vaccine. BMC Pediatrics,15(Article No. 162).

Document type: Journal Article
Citation counts: Altmetric Score Altmetric Score is 8
Google Scholar Search Google Scholar
Attached Files (Some files may be inaccessible until you login with your CDU eSpace credentials)
Name Description MIMEType Size Downloads
Download this reading Leach_59125.pdf Published version application/pdf 648.30KB 18
Reading the attached file works best in Firefox, Chrome and IE 9 or later.

IRMA ID 10444xPUB5
Title Reduced middle ear infection with non-typeable Haemophilus influenzae, but not Streptococcus pneumoniae, after transition to 10-valent pneumococcal non-typeable H. influenzae protein D conjugate vaccine
Author Leach, Amanda J.
Wigger, Christine
Hare, Kim M.
Hampton, Vanya R. S.
Beissbarth, Jemima
Andrews, Ross M.
Chatfield, Mark D.
Smith-Vaughan, Heidi C.
Morris, Peter S.
Journal Name BMC Pediatrics
Publication Date 2015
Volume Number 15
Issue Number Article No. 162
ISSN 1471-2431   (check CDU catalogue  open catalogue search in new window)
Scopus ID 2-s2.0-84944408025
Total Pages 13
Place of Publication United Kingdom
Publisher BioMed Central Ltd.
HERDC Category C1 - Journal Article (DIISR)
Abstract Background
In October 2009, 7-valent pneumococcal conjugate vaccine (PCV7: PrevenarTM Pfizer) was replaced in the Northern Territory childhood vaccination schedule by 10-valent pneumococcal Haemophilus influenzae protein D conjugate vaccine (PHiD-CV10; Synflorix™ GlaxoSmithKline Vaccines). This analysis aims to determine whether the reduced prevalence of suppurative otitis media measured in the PHiD-CV10 era was associated with changes in nasopharyngeal (NP) carriage and middle ear discharge (ED) microbiology in vaccinated Indigenous children.

Methods
Swabs of the NP and ED were collected in remote Indigenous communities between September 2008 and December 2012. Swabs were cultured using standardised methods for otitis media pathogens. Children less than 3 years of age and having received a primary course of 2 or more doses of one PCV formulation and not more than one dose of another PCV formulation were included in the primary analysis; children with non-mixed single formulation PCV schedules were also compared.

Results
NP swabs were obtained from 421 of 444 (95 %) children in the PCV7 group and 443 of 451 (98 %) children in the PHiD-CV10 group. Non-mixed PCV schedules were received by 333 (79 %) and 315 (71 %) children, respectively. Pneumococcal (Spn) NP carriage was 76 % and 82 %, and non-typeable Haemophilus influenzae (NTHi) carriage was 68 % and 73 %, respectively. ED was obtained from 60 children (85 perforations) in the PCV7 group and from 47 children (59 perforations) in the PHiD-CV10 group. Data from bilateral perforations were combined. Spn was cultured from 25 % and 18 %, respectively, and NTHi was cultured from 61 % and 34 % respectively (p = 0.008).

Conclusions
The observed reduction in the prevalence of suppurative OM in this population was not associated with reduced NP carriage of OM pathogens. The prevalence of NTHi-infected ED was lower in PHiD-CV10 vaccinated children compared to PCV7 vaccinated children. Changes in clinical severity may be explained by the action of PHiD-CV10 on NTHi infection in the middle ear. Randomised controlled trials are needed to answer this question.
Keywords Nasopharynx
Streptococcus pneumoniae
Nontypeable Haemophilus influenzae
Otitis media
Child
Indigenous
Pneumococcal vaccines
Prevalence
Surveillance
Risk factors
DOI http://dx.doi.org/10.1186/s12887-015-0483-8   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
Additional Notes This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Description for Link Link to CC Attribution 4.0 License
URL https://creativecommons.org/licenses/by/4.0/au


© copyright

Every reasonable effort has been made to ensure that permission has been obtained for items included in CDU eSpace. If you believe that your rights have been infringed by this repository, please contact digitisation@cdu.edu.au.

 
Versions
Version Filter Type
Access Statistics: 36 Abstract Views, 18 File Downloads  -  Detailed Statistics
Created: Tue, 26 Jul 2016, 12:47:06 CST