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Preserved Dendritic Cell HLA-DR Expression and Reduced Regulatory T Cell Activation in Asymptomatic Plasmodium falciparum and P. vivax Infection

Kho, Steven, Marfurt, Jutta, Noviyanti, Rintis, Kusuma, Andreas, Piera, Kim A., Burdam, Faustina H., Kenangalem, Enny, Lampah, Daniel A., Engwerda, Christian R., Poespoprodjo, Jeanne R., Price, Ric N., Anstey, Nicholas M., Minigo, Gabriela and Woodberry, Tonia (2015). Preserved Dendritic Cell HLA-DR Expression and Reduced Regulatory T Cell Activation in Asymptomatic Plasmodium falciparum and P. vivax Infection. Infection and Immunity,83(8):3224-3232.

Document type: Journal Article
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IRMA ID 11381xPUB103
Title Preserved Dendritic Cell HLA-DR Expression and Reduced Regulatory T Cell Activation in Asymptomatic Plasmodium falciparum and P. vivax Infection
Author Kho, Steven
Marfurt, Jutta
Noviyanti, Rintis
Kusuma, Andreas
Piera, Kim A.
Burdam, Faustina H.
Kenangalem, Enny
Lampah, Daniel A.
Engwerda, Christian R.
Poespoprodjo, Jeanne R.
Price, Ric N.
Anstey, Nicholas M.
Minigo, Gabriela
Woodberry, Tonia
Journal Name Infection and Immunity
Publication Date 2015
Volume Number 83
Issue Number 8
ISSN 0019-9567   (check CDU catalogue open catalogue search in new window)
Scopus ID 2-s2.0-84937793021
Start Page 3224
End Page 3232
Total Pages 9
Place of Publication United States
Publisher American Society for Microbiology
Field of Research MEDICAL AND HEALTH SCIENCES
HERDC Category C1 - Journal Article (DIISR)
Abstract Clinical illness with Plasmodium falciparum or Plasmodium vivax compromises the function of dendritic cells (DC) and expands regulatory T (Treg) cells. Individuals with asymptomatic parasitemia have clinical immunity, restricting parasite expansion and preventing clinical disease. The role of DC and Treg cells during asymptomatic Plasmodium infection is unclear. During a cross-sectional household survey in Papua, Indonesia, we examined the number and activation of blood plasmacytoid DC (pDC), CD141+, and CD1c+ myeloid DC (mDC) subsets and Treg cells using flow cytometry in 168 afebrile children (of whom 15 had P. falciparum and 36 had P. vivax infections) and 162 afebrile adults (of whom 20 had P. falciparum and 20 had P. vivax infections), alongside samples from 16 patients hospitalized with uncomplicated malaria. Unlike DC from malaria patients, DC from children and adults with asymptomatic, microscopy-positive P. vivax or P. falciparum infection increased or retained HLA-DR expression. Treg cells in asymptomatic adults and children exhibited reduced activation, suggesting increased immune responsiveness. The pDC and mDC subsets varied according to clinical immunity (asymptomatic or symptomatic Plasmodium infection) and, in asymptomatic infection, according to host age and parasite species. In conclusion, active control of asymptomatic infection was associated with and likely contingent upon functional DC and reduced Treg cell activation.
DOI http://dx.doi.org/10.1128/IAI.00226-15   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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