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High burden of diabetic foot infections in the top end of Australia: An emerging health crisis (DEFINE study)

Commons, Robert J., Robinson, Claire H., Gawler, David, Davis, Joshua S. and Price, Ric N. (2015). High burden of diabetic foot infections in the top end of Australia: An emerging health crisis (DEFINE study). Diabetes Research and Clinical Practice,110(2):147-157.

Document type: Journal Article
Citation counts: Altmetric Score Altmetric Score is 11
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IRMA ID 11381xPUB173
Title High burden of diabetic foot infections in the top end of Australia: An emerging health crisis (DEFINE study)
Author Commons, Robert J.
Robinson, Claire H.
Gawler, David
Davis, Joshua S.
Price, Ric N.
Journal Name Diabetes Research and Clinical Practice
Publication Date 2015
Volume Number 110
Issue Number 2
ISSN 0168-8227   (check CDU catalogue open catalogue search in new window)
Start Page 147
End Page 157
Total Pages 11
Place of Publication Ireland
Publisher Elsevier Ireland Ltd.
Field of Research MEDICAL AND HEALTH SCIENCES
HERDC Category C1 - Journal Article (DIISR)
Abstract Introduction
The risk of diabetes mellitus is increasing worldwide, and is particularly high in Indigenous Australians. Complicated foot infection is one of the most common sequelae of diabetes. We describe the incidence and associations of Indigenous and non-Indigenous inpatients with diabetic foot infections at Royal Darwin Hospital.

Methods

All adult Royal Darwin Hospital inpatients with diabetic foot infections were enrolled prospectively from September 2012 to November 2013. Incidence, demographics, microbiology, management and clinical outcomes were analysed by Indigenous status, and association with methicillin resistant Staphylococcus aureus and Pseudomonas aeruginosa.

Results

There were 245 separate hospital admissions in 177 patients with an incidence of 79 admissions per 100,000 person years. Patients occupied a mean of 19.4 hospital beds each day. Compared to the non-Indigenous population, Indigenous patients had a greater incidence of admission (Rate Ratio (RR) = 5.1, [95%CI = 3.8, 7.0]), were younger (mean difference of 11.1 years; p < 0.001), and more likely to undergo major and minor amputations (RR = 4.1 [95%CI = 1.6, 10.7], and 6.2 [95%CI = 3.5, 11.1] respectively). Non-multiresistant methicillin resistant S. aureus was present in 44.7% of wounds from Indigenous patients versus 20.6% of non-Indigenous patients (Odds Ratio (OR) = 3.1, [95%CI = 1.5, 6.4]), whereas P. aeruginosa presence was significantly lower (15.8% versus 46.0%; OR = 0.22; [95%CI = 0.11, 0.45]). Methicillin resistant S. aureus or P. aeruginosa infections were associated with longer antibiotic courses and durations of stay.

Conclusions

This study highlights a rising burden of diabetic foot infections in the Top End of Australia, with a four-fold increase in bed days since 2002 and an overrepresentation in the Indigenous population.
Keywords Diabetes mellitus
Diabetic foot infection
Indigenous
Australia
Methicillin resistant Staphylococcus aureus
Pseudomonas aeruginosa
DOI http://dx.doi.org/10.1016/j.diabres.2015.09.016   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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