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Asymptomatic and submicroscopic carriage of Plasmodium knowlesi malaria in household and community members of clinical cases in Sabah, Malaysia

Fornace, Kimberly M., Nuin, Nor A., Betson, Martha, Grigg, Matthew J., William, Timothy, Anstey, Nicholas M., Yeo, Tsin W., Cox, Jonathan, Ying, Lau T. and Drakeley, Chris J. (2016). Asymptomatic and submicroscopic carriage of Plasmodium knowlesi malaria in household and community members of clinical cases in Sabah, Malaysia. Journal of Infectious Diseases,213(5):784-787.

Document type: Journal Article
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IRMA ID 10444xPUB15
Title Asymptomatic and submicroscopic carriage of Plasmodium knowlesi malaria in household and community members of clinical cases in Sabah, Malaysia
Author Fornace, Kimberly M.
Nuin, Nor A.
Betson, Martha
Grigg, Matthew J.
William, Timothy
Anstey, Nicholas M.
Yeo, Tsin W.
Cox, Jonathan
Ying, Lau T.
Drakeley, Chris J.
Journal Name Journal of Infectious Diseases
Publication Date 2016
Volume Number 213
Issue Number 5
ISSN 0022-1899   (check CDU catalogue  open catalogue search in new window)
Scopus ID 2-s2.0-84958592196
Start Page 784
End Page 787
Total Pages 4
Place of Publication United States
Publisher Oxford University Press
Field of Research MEDICAL AND HEALTH SCIENCES
HERDC Category C1 - Journal Article (DIISR)
Abstract Although asymptomatic carriage of human malaria species has been widely reported, the extent of asymptomatic, submicroscopic Plasmodium knowlesi parasitemia is unknown. In this study, samples were obtained from individuals residing in households or villages of symptomatic malaria cases with the aim of detecting submicroscopic P. knowlesi in this population. Four published molecular assays were used to confirm the presence of P. knowlesi. Latent class analysis revealed that the estimated proportion of asymptomatic individuals was 6.9% (95% confidence interval, 5.6%–8.4%). This study confirms the presence of a substantial number of asymptomatic monoinfections across all age groups; further work is needed to estimate prevalence in the wider community.
Keywords malaria
Plasmodium knowlesi
submicroscopic infection
asymptomatic parasitemia
DOI http://dx.doi.org/10.1093/infdis/jiv475   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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Created: Tue, 26 Jul 2016, 12:50:36 CST