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A cluster-randomised controlled trial integrating a community-based water, sanitation and hygiene program with mass albendazole to reduce intestinal parasites in Timor-Leste: the WASH for WORMS research protocol

Nery, Susana Vaz, McCarthy, James S., Traub, Rebecca, Andrews, Ross M., Black, Jim, Gray, Darren, Weking, Edmund, Atkinson, Jo-An, Campbell, Suzy, Francis, Naomi, Vallely, Andrew, Williams, Gail and Clements, Archie (2015). A cluster-randomised controlled trial integrating a community-based water, sanitation and hygiene program with mass albendazole to reduce intestinal parasites in Timor-Leste: the WASH for WORMS research protocol. BMJ Open,5(12 - Article No. e009293).

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Title A cluster-randomised controlled trial integrating a community-based water, sanitation and hygiene program with mass albendazole to reduce intestinal parasites in Timor-Leste: the WASH for WORMS research protocol
Author Nery, Susana Vaz
McCarthy, James S.
Traub, Rebecca
Andrews, Ross M.
Black, Jim
Gray, Darren
Weking, Edmund
Atkinson, Jo-An
Campbell, Suzy
Francis, Naomi
Vallely, Andrew
Williams, Gail
Clements, Archie
Journal Name BMJ Open
Publication Date 2015
Volume Number 5
Issue Number 12 - Article No. e009293
ISSN 2044-6055   (check CDU catalogue open catalogue search in new window)
Total Pages 12
Place of Publication United Kingdom
Publisher B M J Group
HERDC Category C1 - Journal Article (DIISR)
Abstract Introduction There is limited evidence demonstrating the benefits of community-based water, sanitation and hygiene (WASH) programmes on infections with soil-transmitted helminths (STH) and intestinal protozoa. Our study aims to contribute to that evidence base by investigating the effectiveness of combining two complementary approaches for control of STH: periodic mass administration of albendazole, and delivery of a community-based WASH programme.

Methods and analysis WASH for WORMS is a cluster-randomised controlled trial to test the hypothesis that a community-based WASH intervention integrated with periodic mass distribution of albendazole will be more effective in reducing infections with STH and protozoa than mass deworming alone. All 18 participating rural communities in Timor-Leste receive mass chemotherapy every 6 months. Half the communities also receive the community-based WASH programme. Primary outcomes are the cumulative incidence of infection with STH. Secondary outcomes include the prevalence of protozoa; intensity of infection with STH; as well as morbidity indicators (anaemia, stunting and wasting). Each of the trial outcomes will be compared between control and intervention communities. End points will be measured 2 years after the first albendazole distribution; and midpoints are measured at 6 months intervals (12 months for haemoglobin and anthropometric indexes). Mixed-methods research will also be conducted in order to identify barriers and enablers associated with the acceptability and uptake of the WASH programme.

Ethics and dissemination Ethics approval was obtained from the human ethics committees at the University of Queensland, Australian National University, Timorese Ministry of Health, and University of Melbourne. The results of the trial will be published in peer-reviewed journals presented at national and international conferences, and disseminated to relevant stakeholders in health and WASH programmes. This study is funded by a Partnership for Better Health—Project grant from the National Health and Research Council (NHMRC), Australia.

Trial registration number ACTRN12614000680662; Pre-results
DOI http://dx.doi.org/10.1136/bmjopen-2015-009293   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
Additional Notes This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Description for Link Link to CC Attribution 4.0 License
URL https://creativecommons.org/licenses/by/4.0/au


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