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Cognition and nocturnal disturbance in OSA: the importance of accounting for age and premorbid intelligence

Olaithe, Michelle, Skinner, Timothy C., Hillman, David, Eastwood, Peter E. and Bucks, Romola S. (2015). Cognition and nocturnal disturbance in OSA: the importance of accounting for age and premorbid intelligence. Sleep and Breathing,19(1):221-230.

Document type: Journal Article
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IRMA ID 82794376xPUB283
Title Cognition and nocturnal disturbance in OSA: the importance of accounting for age and premorbid intelligence
Author Olaithe, Michelle
Skinner, Timothy C.
Hillman, David
Eastwood, Peter E.
Bucks, Romola S.
Journal Name Sleep and Breathing
Publication Date 2015
Volume Number 19
Issue Number 1
ISSN 1520-9512   (check CDU catalogue open catalogue search in new window)
Scopus ID 2-s2.0-84929022995
Start Page 221
End Page 230
Total Pages 10
Place of Publication Germany
Publisher Springer
HERDC Category C1 - Journal Article (DIISR)
Abstract Introduction
Obstructive sleep apnea (OSA) is a common disorder that is associated with impaired attention, memory and executive function. However, the mechanisms underlying such dysfunction are unclear. To determine the influence of sleep fragmentation and hypoxia, this study examined the effect of sleep fragmentation and hypoxia on cognition in OSA, while controlling for potentially confounding variables including sleepiness, age and premorbid intelligence.

Method
Participants with and without OSA (N = 150) were recruited from the general community and a tertiary hospital sleep clinic. All underwent comprehensive, laboratory-based polysomnography (PSG) and completed assessments of cognition including attention, short- and long-term memory and executive function. Structural equation modelling (SEM) was used to construct a theoretically-driven model to examine the relationships between hypoxia and sleep fragmentation, and cognitive function.

Results
Although after controlling for IQ, increased sleep disturbance was a significant predictor of decreased attention (p = 0.04) and decreased executive function (p = 0.05), controlling for age removes these significant relationships. No significant predictors of memory function were found.

Conclusions
The mechanisms underlying the effects of OSA on cognition remain to be defined. Implications are discussed in light of these findings.
Keywords OSA
AHI
Cognition
Neuropsychology
Structural Equation Modelling
DOI http://dx.doi.org/10.1007/s11325-014-1000-2   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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