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Bone cancer incidence by morphological subtype: a global assessment

Valery, Patricia C., Laversanne, Mathieu and Bray, Freddie (2015). Bone cancer incidence by morphological subtype: a global assessment. Cancer Causes and Control,26(8):1127-1139.

Document type: Journal Article
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IRMA ID 75039815xPUB930
Title Bone cancer incidence by morphological subtype: a global assessment
Author Valery, Patricia C.
Laversanne, Mathieu
Bray, Freddie
Journal Name Cancer Causes and Control
Publication Date 2015
Volume Number 26
Issue Number 8
ISSN 0957-5243   (check CDU catalogue  open catalogue search in new window)
Scopus ID 2-s2.0-84937637123
Start Page 1127
End Page 1139
Total Pages 13
Place of Publication Netherlands
Publisher Springer Netherlands
HERDC Category C1 - Journal Article (DIISR)
Abstract Purpose
To better understand the relevance of environmental factors to the changing patterns of bone cancer subtypes, we examine the incidence of osteosarcoma (OS), Ewing sarcoma (ES), and chondrosarcoma (CS) using data from cancer incidence in five continents.

Methods

Age-specific and age-standardized incidence rates (ASRs) per 100,000 person-years were computed and stratified by country (n = 43), subtype, and sex during 2003–2007. Temporal patterns of ASRs were examined during 1988–2007 (12 countries). Age–period–cohort models were fitted for the USA and UK by subtype.

Results

For most countries, OS represented 20–40 % of all bone cancers, ES < 20 %, while CS proportions varied more considerably. Overall ASRs of bone cancers were 0.8–1.2/100,000 in men and 0.5–1.0 in women (0.20–0.35/100,000 for OS and 0.10–0.30/100,000 for CS in both men and women, and <0.10–0.25/100,000 in men and 0.05–0.25/100,000 in women for ES). The age-specific incidence rates revealed a bimodal peak of OS, one peak of ES in childhood, and a more heterogeneous pattern for CS. The overall bone cancer incidence trends are generally flat, but more heterogeneous for ES and CS. A declining OS incidence was observed in the UK and USA (men), an increase in CS in the UK and USA (female), and an apparent increase in ES, followed by a leveling off in successive US and UK cohorts.

Conclusion

Monitoring bone cancer incidence trends with data assembled from a geographically broader range of registries may generate hypotheses about additional risk factors and ensure that high-risk populations are not overlooked in cancer control efforts.
Keywords Bone
Cancer
Incidence
Worldwide
DOI http://dx.doi.org/10.1007/s10552-015-0607-3   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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Created: Tue, 26 Jul 2016, 12:51:55 CST